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MetabolomicsPhosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans
Metabolic stress due to nutrient excess and lipid accumulation is at the root of many age-associated disorders and the identification of therapeutic targets that mimic the beneficial effects of calorie restriction has clinical importance. Here, using C. elegans as a model organism, we study the role...
2021-09-28 | MTBLS3485 | MetaboLights
GenomicsSystemic lipolysis promotes healthspan in Drosophila melanogaster
Systemic lipolysis promotes healthspan in Drosophila melanogaster
PRJNA741136 | ENA
GenomicsLow-dose quercetin positively regulates mouse healthspan
Low-dose quercetin positively regulates mouse healthspan
PRJNA545993 | ENA
UnknownA proteomic signature of healthspan.
Not available
S-EPMC11230312 | biostudies-literature
UnknownA proteomic signature of healthspan.
Not available
S-EPMC12168021 | biostudies-literature
TranscriptomicsSystemic lipolysis promotes healthspan in Drosophila melanogaster
Since healthspan-extending interventions such as caloric restriction or fasting robustly promote lipid catabolism, we investigated how lifespan and healthspan were affected by increased lipid catabolism via bmm (brummer, FBgn0036449), the major triglyceride hydrolase in Drosophila. Global overexpres...
ORGANISM(S): Drosophila melanogaster 
2022-09-27 | GSE178816 | GEO
UnknownIndoles from commensal bacteria extend healthspan.
Not available
S-EPMC5594673 | biostudies-literature
TranscriptomicsRNA-seq of different tissues from wild-type and C/EBPα ΔuORF mutant African turquoise killifish Nothobranchius furzeri
The transcription factor CCAAT/enhancer binding protein alpha (C/EBPα) regulates cell differentiation, proliferation, and function in various tissues, including the liver, adipose tissue, skin, lung, and hematopoietic system. Studies in rats, mice, humans, and chickens have shown that CEBPA mRNA und...
ORGANISM(S): Nothobranchius furzeri 
2026-05-26 | E-MTAB-15325 | biostudies-arrayexpress
ProteomicsErgothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation
Ergothioneine (ET), a dietary thione/thiol, is receiving growing attention for its possible benefits in healthy aging and metabolic resilience. Our study investigates ET's effects on healthspan in aged animals, revealing extension of lifespan and enhanced mobility in Caenorhabditis elegans, accompan...
ORGANISM(S): Caenorhabditis elegans 
2025-01-21 | PXD051587 | Pride
Ergothioneine Healthspan Persulfidation Hydrogen sulfide Nad 
GenomicsIncreased hyaluronan by naked mole-rat HAS2 extends healthspan in mice
Increased hyaluronan by naked mole-rat HAS2 extends healthspan in mice
PRJNA982056 | ENA
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