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ProteomicsSulfide Regulates Autophagy by Reversible Persulfidation of the Cysteine Protease ATG4
Hydrogen sulfide is a signaling molecule that regulates essential processes for plant performance, such as autophagy. In Arabidopsis thaliana, hydrogen sulfide negatively regulates autophagy independently of reactive oxygen species, but the underlying mechanism remains to be understood. To determine...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-12-14 | PXD019802 | Pride
Abscisic acid Arabidopsis Persulfidation Hydrogen sulfide 
ProteomicsPersulfidation of plant and bacteroid proteins is involved in legume nodule development and senescence
Legumes establish symbiosis with soil rhizobia forming root nodules that fix atmospheric nitrogen. The central role of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in nodule biology has been clearly established. Recently, hydrogen sulfide (H2S) and other reactive sulfur species ...
ORGANISM(S): Phaseolus vulgaris (Kidney bean) (French bean) 
2024-06-16 | PXD039852 | Pride
Legumes Nodule development Post-translational modifications Symbiosis Persulfidation Nodule senescence Redox regulation 
GenomicsPersulfidation affects gene regulatory programs and promotes in endothelial specification
Persulfidation alters gene regulatory programs and promotes endothelial specification
PRJEB101608 | ENA
ProteomicsPathology-driven epithelial sulfide loss reprograms the redox proteome and triggers Barrett’s esophagus
Background & AimsBarrett’s esophagus (BE), a metaplastic transformation driven by gastroesophageal reflux disease (GERD), induces oxidative stress but the underlying redox mechanisms remain poorly understood. Protein persulfidation (PSSH), a redox-sensitive, reversible, and antioxidative post-transl...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD047338 | Pride
Persulfidation  hydrogen sulfide  barrett’s esophagus  gastroesophageal reflux disease (gerd)  prostaglandin e2/interleukin 1/mtor cross-talk 
ProteomicsErgothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation
Ergothioneine (ET), a dietary thione/thiol, is receiving growing attention for its possible benefits in healthy aging and metabolic resilience. Our study investigates ET's effects on healthspan in aged animals, revealing extension of lifespan and enhanced mobility in Caenorhabditis elegans, accompan...
ORGANISM(S): Caenorhabditis elegans 
2025-01-21 | PXD051587 | Pride
Ergothioneine Healthspan Persulfidation Hydrogen sulfide Nad 
ProteomicsNeurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, H2S overproduction, altered protein persulfidation, synaptic dysfunction, endoplasmic reticulum stress, and autophagy
Down syndrome (DS) is a genetic condition where the person is born with an extra chromosome 21. DS is associated with accelerated aging; people with DS are prone to age-related neurological conditions including an early-onset Alzheimer’s disease. Using the Dp(17)3Yey/ + mice, which overexpresses a p...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-30 | PXD048079 | Pride
Hydrogen sulfide  bioenergetics  gasotransmitters  proliferation  mitochondria 
ProteomicsAntagonistic regulation of apoptosis by polysulfides and thioredoxin via persulfidation of caspases
Hydrogen sulfide has been implicated in a large number of physiological processes including cell survival and death, encouraging research into its mechanisms of action and therapeutic potential. Recent studies suggest that the cellular effects of hydrogen sulfide are mediated in part by sulfane sulf...
ORGANISM(S): Homo sapiens (Human) 
2020-02-18 | PXD017144 | Pride
Thioredoxin Persulfidation Polysulfides Apoptosis Caspases 
ProteomicsPersulfidation alters gene regulatory programs and promotes endothelial specification
Endogenously generated sulfides are conserved among species and tissues and exert multiple effects through diverse mechanisms. Although sulfides have been linked to cell fates, their role in pluripotent stem cell commitment remains unknown. Here we discovered that during directed differentiation of ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD071015 | Pride
Sulfide supplementation Endothelial commitment Persulfidation Stem cells 
ProteomicsChemoselective Proteomics, Zinc Fingers, and a Zinc(II) Model for H2S Mediated Persulfidation
The gasotransmitter hydrogen sulfide (H2S) is thought to be involved in the post-translational modification of cysteine residues to produce reactive persulfides. A persulfide-specific chemoselective proteomics approach with mammalian cells has identified a broad range of zinc finger (ZF) proteins as...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-23 | PXD041310 | Pride
Zinc-sulfide Zinc-finger H2s Persulfidation 
ProteomicsE2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation
Posttranslational modifications by ubiquitin-like proteins (UBL) are essential for nearly all cellular processes. Ubiquitin related modifier 1 (Urm1) is a non-canonical UBL which plays a key role in tRNA anticodon thiolation as a sulfur carrier protein (SCP). While Urm1 has also been observed to con...
ORGANISM(S): Chaetomium Thermophilum (ncbitaxon:209285) Saccharomyces Cerevisiae (ncbitaxon:4932) Homo Sapiens (ncbitaxon:9606) 
2021-11-16 | MSV000088390 | MassIVE
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