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MetabolomicsCTH exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have highlighted the importance of macrophage immunometabolism in their activation state and function...
2022-06-14 | MTBLS2851 | MetaboLights
GenomicsThe role of CTH in the innate immune response to H. pylori
The role of CTH in the innate immune response to H. pylori
PRJNA666648 | ENA
UnknownCystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation.
Not available
S-EPMC10363444 | biostudies-literature
MetabolomicsBacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show that the enzyme cystathionine γ-lyase (CTH) is induced in macrophages infected with pathogenic ba...

2020-05-15 | MTBLS696 | MetaboLights
UnknownCth/Mpst double ablation results in early onset fatty liver disease in lean mice.
Not available
S-EPMC12023873 | biostudies-literature
TranscriptomicsThe role of CTH in the innate immune response to H. pylori
RNA sequencing by Illumina NovaSeq6000 was performed on F4/80 positive cells isolated from the gastric tissue of mice infected or not with H. pylori SS1 for 16 weeks to determine the role of CTH in the innate immune response in the stomach.
ORGANISM(S): Mus musculus 
2022-05-18 | GSE158817 | GEO
UnknownSENP3 Drives Abdominal Aortic Aneurysm Development by Regulating Ferroptosis via De-SUMOylation of CTH.
Not available
S-EPMC12021093 | biostudies-literature
UnknownNOS3 and CTH gene mutations as new molecular markers for detection of lung adenocarcinoma.
Not available
S-EPMC10722981 | biostudies-literature
UnknownCTH/H2S Regulates LPS-Induced Inflammation through IL-8 Signaling in MAC-T Cells.
Not available
S-EPMC9570289 | biostudies-literature
UnknownCystathionine gamma-lyase (Cth) induces efferocytosis in macrophages via ERK1/2 to modulate intestinal barrier repair.
Not available
S-EPMC9869634 | biostudies-literature
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