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ProteomicsProof of concept a new plasma complement Factor H from waste plamsa fraction
Introduction: Complement factor H (FH) is a major regulator of the complement alternative pathway, its mutations predispose to an uncontrolled activation in the kidney and on blood cells and to secondary C3 deficiency. Plasma exchange has been used to correct for FH deficiency and although the thera...
ORGANISM(S): Homo sapiens (Human) 
2024-03-27 | PXD050268 | Pride
Concentrated complement factor h  plasma purification 
TranscriptomicsTranscription profiling by array of dendritic cells from three different human donors to characterize the impact of differential HIV opsonization on dendritic cell modulation
The aim of this study was to characterize the impact of differential HIV opsonization on DC modulation. DCs are the most potent antigen-presenting cells and among the first cells HIV is attaching to. HIV spontaneously activates the complement system even in the absence of specific antibodies and is ...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-MEXP-3706 | biostudies-arrayexpress
ProteomicsTFMI-3 plasma pull-down - MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked
MASP-3 is the third protease of the lectin pathway of the complement system, but its biological function has remained obscure. To elucidate its role in complement activation, we developed a specific MASP-3 inhibitor (named TFMI-3). In this work we unambiguously demonstrate that MASP-3 acts as the ex...
ORGANISM(S): Homo sapiens (Human) 
2016-08-24 | PXD003666 | Pride
Factor d Complement Alternative pathway Inhibitor Masp-3 Blood Directed protein evolution Lectin pathway 
TranscriptomicsTranscriptomic response to concentrated pea root exudate
The secretion of metabolites by plant roots is a key determinant of microbial growth and colonisation. We have used Pisum sativum and its natural symbiont Rhizobium leguminosarum (it can form N2 fixing nodules on pea roots) to study the natural metabolites secreted by roots. To do this root secretio...
ORGANISM(S): Rhizobium leguminosarum 
2016-05-25 | E-MTAB-4790 | biostudies-arrayexpress
ProteomicsN-terminomics profiling of host proteins targeted by excretory-secretory proteases of the nematode Angiostrongylus vasorum identifies points of interaction with canine coagulation and complement cascade
The cardiopulmonary nematode Angiostrongylus vasorum can cause severe disease in dogs, including coagulopathies manifesting with bleeding. We analysed A. vasorum excretory/secretory protein (ESP)-treated dog plasma and serum by N-terminome analysis using Terminal Amine Isotopic Labelling of Substrat...
ORGANISM(S): Angiostrongylus vasorum Canis familiaris (Dog) (Canis lupus familiaris) 
2025-05-07 | PXD056659 | Pride
Dog Serum French heartworm Plasma Tails 
UnknownVitamin D deficiency leads to the abnormal activation of the complement system.
Not available
S-EPMC9845165 | biostudies-literature
UnknownComplement activation by autoantigen recognition in the growth process of benign prostatic hyperplasia.
Not available
S-EPMC6937285 | biostudies-literature
ProteomicsPathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury
Intestinal ischemia-reperfusion (IR) injury is initiated when natural IgM antibodies recognize neo-epitopes that are revealed on ischemic cells. The target molecules and mechanisms whereby these neo-epitopes become accessible to recognition are not well understood. Proposing that isolated intestinal...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14862 | biostudies-arrayexpress
UnknownCell-surface receptor for complement component C1q (gC1qR) is a key regulator for lamellipodia formation and cancer metastasis.
Not available
S-EPMC3123076 | biostudies-literature
TranscriptomicsTranscription profiling of human CD34+ stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor
Mononuclear cells were isolated from granulocyte colony stimulating factor mobilised peripheral blood. CD34+ cells were selected and separated into adherent and non-adherent cells. Adherent and non-adherent samples were amplified and labelled using two IVT cycles, and gene expression profiling was p...
ORGANISM(S): Homo sapiens 
2008-08-01 | E-MIMR-861 | biostudies-arrayexpress
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