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MetabolomicsConformational gating mechanism for processive catalysis of beta(1,3) -glucans

Processive catalysis is a fundamental molecular mechanism in nature to both build and dismantle complex biological polymers such as nucleic acids, proteins and carbohydrates, underpinning a broad spectrum of biotechnological applications. Here, we uncover a processive mechanism for the breakdown ...

2026-03-02 | MTBLS13959 | MetaboLights
ProteomicsLarge-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins using Limited Proteolysis
Conformational changes in proteins can lead to disease. Thus, methods for identifying conformational changes in proteins can further improve our understanding and facilitate detection of disease states. Here we combine limited proteolysis (LiP) with Stable Isotope Labeling with Amino Acids in Cell ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080770 | MassIVE
MetabolomicsLipidomic Changes in the Liver of Beagle Dogs Associated with Toxocara canis Infection

In this study, lipid alterations in Beagle dog’s liver caused by Toxocara canis infection were investigated by using liquid chromatography with tandem mass spectrometry at 12 hours post infection (hpi), 24 hpi and 36 days post infection (dpi). A total of 6 categories and 42 subclasses of...

2022-08-30 | MTBLS4015 | MetaboLights
ProteomicsIsobaric crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and complexes
Dynamic conformational and structural changes in proteins and protein complexes play a central and ubiquitous role in the regulation of protein function, yet it is very challenging to study these changes, especially for large protein complexes, under physiological conditions. Here we introduce a nov...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-11-13 | PXD056825 | Pride
Isobaric crosslinkers Qclms Conformational changes Quantitative crosslinking mass spectrometry 
ProteomicsLarge-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins using Limited Proteolysis
Conformational changes in proteins can lead to disease. Thus, methods for identifying conformational changes in proteins can further improve our understanding and facilitate detection of disease states. Here we combine limited proteolysis (LiP) with Stable Isotope Labeling with Amino Acids in Cell ...
ORGANISM(S): Homo sapiens (Human) 
2016-12-23 | PXD005210 | Pride
Proteomics Limited proteolysis Mass spectrometry Silac Mcf-10a Mcf-7 Protein folding 
ProteomicsExploring the interplay between protein conformational changes and phosphorylation in a pancreatic cancer cell and stellate cell co-culture system
A global exploration of the complex interplay between protein conformational changes and phosphorylation events in cell-cell interactions is crucial for understanding the dynamic nature of protein modifications. This understanding is essential for developing novel targeted therapies for pancreatic c...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD059270 | Pride
ProteomicsStructural mass spectrometry captures residue-resolved comprehensive conformational rearrangements of a G protein-coupled receptor
GPCR structural studies with in-solution spectroscopic approaches have offered distinctive insights into GPCR activation and signaling that highly complement those yielded from structural snapshots by crystallography or cryo-EM. While most current spectroscopic approaches excel at probing structural...
ORGANISM(S): Homo Sapiens 
PXD048942 |
ProteomicsSynaptamide activates the adhesion GPCR GPR110 through conformational changes induced by GAIN domain binding
Ligand-induced conformational changes of GPR110 in cells probed by chemical cross-linking and mass specrtometry
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD017128 | Pride
Gpr110 In-cell cross-linking Conformational changes Gain domain Lc-ms/ms 
ProteomicsATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt
We use HDX-MS to interrogate the AKT1 DrLink conformational changes upon binding AKT1 active site inhibitors A-443654, Capivasertib, and Uprosertib, Akt1 allosteric inhibitor MK-2206, and ADP.
ORGANISM(S): Homo sapiens (Human) 
2024-08-23 | PXD039028 | Pride
Akt1 drlink Atp competitive inhibitors Allosteric inhibitors Akt1 Protein kinase b Hdx-ms 
ProteomicsHydrogen-deuterium exchange points to interactions at the helicase - topoisomerase interface in reverse gyrase that play a role in positive DNA supercoiling
Reverse gyrase is a DNA topoisomerase that catalyzes positive DNA supercoiling in an ATP-dependent reaction. The enzyme consists of a helicase and a topoisomerase domain. The isolated helicase-like domain is a DNA-stimulated ATPase, and the isolated topoisomerase domain can relax supercoiled DNA. Fo...
ORGANISM(S): Thermotoga maritima 
2026-08-24 | PXD074413 | Pride
Topoisomerase Helicase Reverse gyrase Conformational changes Positive dna supercoiling 
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