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ProteomicsMetagenomic and metaproteomic analyses of microbial amino acid metabolism during Cantonese soy sauce fermentation
metagenomic and metaproteomic analyses were used to identify the changes in the dominant flora and related enzymes in amino acid synthesis and metabolism during Cantonese soy sauce fermentation.
ORGANISM(S): Aspergillus Oryzae Enterobacter Hormaechei Weissella Paramesenteroides Weissella Confusa Tetragenococcus Halophilus 
2023-10-19 | PXD046225 |
MetabolomicsGut microbiota ameliorates hepatic fibrosis through modulating intestinal bile acid metabolism and hepatocyte pyroptosis (Hepatic fibrosis feces)

Hepatic fibrosis decreased feces bile acid level. Hepatic fibrosis increased serum bile acid. This result showed that hepatic fibrosis inhibited the excretion of bile acid in clinical patients. This result provided phenotype for hepatic fibrosis patients. Bile acid was important indexes for liver...

2023-03-17 | MTBLS6742 | MetaboLights
MetabolomicsGut microbiota ameliorates hepatic fibrosis through modulating intestinal bile acid metabolism and hepatocyte pyroptosis (Hepatic fibrosis serum+feces)

Parabacteroides distasonis (P. distasonis) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that P. distasonis is decreased in patients with hepatic fibrosis, and that administration of P. dista...

2023-03-17 | MTBLS6728 | MetaboLights
MetabolomicsGut microbiota ameliorates hepatic fibrosis through modulating intestinal bile acid metabolism and hepatocyte pyroptosis (Hepatic fibrosis serum)

Hepatic fibrosis decreased feces bile acid level. Hepatic fibrosis increased serum bile acid. This result showed that hepatic fibrosis inhibited the excretion of bile acid in clinical patients. This result provided phenotype for hepatic fibrosis patients. Bile acid was important indexes for liver...

2023-03-17 | MTBLS6732 | MetaboLights
ProteomicsNMT2 alleviated the depression-like behavior：integrated proteomic and phosphoproteomic analysis of chronic unpredictable stress in rats
Proteomics has been widely used to investigate multiple diseases, and combining proteomics with phosphoproteomics analysis would further explain the pathological mechanisms of depression. The study induced depression-like behavior in rats using CUMS and conducted sucrose preference test, open field ...
ORGANISM(S): Rattus Rattus 
2024-03-18 | PXD050750 |
ProteomicsDeep metaproteomics of inflammatory bowel diseases
Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is associated with a loss or an imbalance of host-microbe interactions. Depletion-assisted deep metaproteomics was employed to reveal disease-specific networks of host-microbial protein associations in IBD...
ORGANISM(S): Homo Sapiens 
2023-06-28 | PXD043380 |
ProteomicsPatient plasma-based immunoproteomics reveals novel Echinococcus granulosus antigens for diagnosis of cystic echinococcosis, LC-MS/MS
Herein, we establish an immuno-proteomics workflow using CE patient tissues and plasma to identify diagnostic Eg antigens. The proteins extracted from the CE surgery tissues were recognized by the patient plasma and identified by mass spectrometry.
ORGANISM(S): Echinococcus Granulosus Granulosus 
2025-11-13 | PXD070671 |
ProteomicsMulti-organ Proteomic and Phosphoproteomic Profiles of Mpox Virus Infection in SIVmac239-infected Rhesus Macaques
Macaque study was conducted in an ABSL-3 facility, adhering to protocols approved by the Institutional Animal Care and Use Committee (IACUC) under the guidelines of the Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (Approval Number XJ23004). All animals were single-hous...
ORGANISM(S): Macaca Mulatta 
2024-10-12 | PXD056753 |
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