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MetabolomicsGestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease
Dysregulated maternal fatty acid metabolism increases the risk of congenital heart disease (CHD) in offspring with an unknown mechanism, and the effect of folic acid fortification in preventing CHD is controversial. Using gas chromatography coupled to either a flame ionization detector or mass spect...
2023-03-24 | MTBLS6982 | MetaboLights
MetabolomicsTranscriptomics integrated with metabolomics reveals partial molecular mechanisms of nutritional risk and neurodevelopment in children with congenital heart disease

PURPOSE: To explore molecular mechanisms affecting nutritional risk and neurodevelopment in children with congenital heart disease (CHD) by combining transcriptome and metabolome analysis.

METHODS: A total of 26 blood and serum samples from 3 groups of chil...

2024-10-25 | MTBLS10118 | MetaboLights
TranscriptomicsTranscriptional Atlas of Cardiogenesis Maps Congenital Heart Disease Interactome
Mammalian heart development is built on highly conserved molecular mechanisms with polygenetic perturbations resulting in a spectrum of congenital heart diseases (CHD). However, the transcriptional landscape of cardiogenic ontogeny that regulates proper cardiogenesis remains largely based on candida...
ORGANISM(S): Mus musculus 
2014-05-19 | E-GEOD-51483 | biostudies-arrayexpress
TranscriptomicsArray CGH in congenital heart disease
Congenital heart disease (CHD) is the most frequent birth defect and affects nearly 1% of newborns. The etiology of CHD is largely unknown and only a small percentage can be assigned to environmental risk factors such as maternal diseases or exposure to mutagenic agents during pregnancy. Chromosomal...
ORGANISM(S): Homo sapiens 
2008-05-11 | E-GEOD-7527 | biostudies-arrayexpress
MetabolomicsAn Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid phenotyping for large epidemiological studies to reveal the detailed associati...
2024-02-02 | MTBLS4461 | MetaboLights
TranscriptomicsArray-CGH in Chinese children with congenital heart disease
We used Affymetrix CytoScan750K array to detect the pathogenic copy number variations in 7 Chinese children with congenital heart disease
ORGANISM(S): Homo sapiens 
2021-10-01 | E-MTAB-8315 | biostudies-arrayexpress
GenomicsCongenital Heart Disease Pilot
This pilot study aims to generate pilot data to inform future study designs by resequencing the whole exomes of 10 unrelated individuals diagnosed with Congenital Heart Disease (CHD).
EGAS00001000425 | EGA
GenomicsExome sequencing of Congenital Heart Disease families Leuven
This project aims to study at least 90 exomes from families with congenital heart disease. The samples have been selected in Leuven in collaboration with Koen Devriendt. Ethic approval has been sought for in Leuven, Belgium and a HDMMC agreement for submitting these samples is in place at the WTSI....
EGAS00001000185 | EGA
GenomicsExome sequencing of Congenital Heart Disease families Toronto
Atrio-ventricular septal defects (AVSD) are a specific form of congenital heart structural defect that result from abnormal or inadequate fusion of endocardial cushions during cardiac development. This project is focused on identifying rare coding variation that substantially increases risk of AVSD,...
EGAS00001000317 | EGA
UnknownEducation as important predictor for successful employment in adults with congenital heart disease worldwide.
Not available
S-EPMC6849520 | biostudies-literature
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