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ProteomicsPneumococcus suppresses host inflammatory response through COMMD2 mediated NF-κB degradation by aggrephagy
NF-κB driven cellular immunity is essential for both pro- and anti-inflammatory responses to microbes, which makes it one of the most frequently targeted pathways by bacteria during pathogenesis. How NF-κB tunes the epithelial response to Streptococcus pneumoniae across the spectrum of commensal to ...
ORGANISM(S): Streptococcus pneumoniae TIGR4 
2026-09-07 | PXD043886 | Pride
Commd2 Nf-κb degradation 
TranscriptomicsTranscription profiling of A549 cells after Pneumococcus 6B ST90 and TIGR4 infection
Compared A549 epithelial cells 2 hrs post-challenge with 6B ST90 CC156 lineage F and TIGR4.
ORGANISM(S): Homo sapiens 
2020-11-10 | E-MTAB-9603 | biostudies-arrayexpress
ProteomicsCommensal-like vs. invasive Pneumococcus p65 interactome
Define the divergent p65 interactome between commensal-like vs. invasive pneumococcal-host interaction.
ORGANISM(S): Homo sapiens (Human) Streptococcus pneumoniae TIGR4 Streptococcus pneumoniae 670-6B 
2026-09-07 | PXD032970 | Pride
P65 Nf-kb Commd Epithelial cells Pneumococcus 
UnknownHER2 chimeric antigen receptor T cell immunotherapy is an effective treatment for diffuse intrinsic pontine glioma.
Not available
S-EPMC10158089 | biostudies-literature
MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
ProteomicsWhole-cell and plasma membrane proteomics of herpes simplex virus-1 infection reveals cell surface remodelling via pUL56-mediated GOPC degradation
Herpesviruses are ubiquitous in the human population and they extensively remodel the cellular environment during infection. Multiplexed quantitative proteomic analysis over the time-course of herpes simplex virus (HSV)-1 infection was used to characterize changes in the host-cell proteome and the k...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2020-10-15 | PXD021351 | Pride
Quantitative proteomics Uncharacterized orf Immune evasion Membrane trafficking Virus host interaction Proteasomal degradation Herpesvirus 
UnknownCCR2-64I polymorphism is not associated with altered CCR5 expression or coreceptor function.
Not available
S-EPMC104492 | biostudies-literature
UnknownFactors affecting heat resilience of drone honey bees (Apis mellifera) and their sperm.
Not available
S-EPMC11805398 | biostudies-literature
TranscriptomicsATAC-seq of oesophageal adenocarcinoma cell line MFD-1
The open chromatin of new esophageal adenocarcinoma cell line MFD-1 has been profiled by ATAC-seq.
ORGANISM(S): Homo sapiens 
2018-04-06 | E-MTAB-6720 | biostudies-arrayexpress
MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
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