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ProteomicsSubtherapeutic-Dose of Ionizing Radiation Reprograms the Pre-Metastatic Lung Niche, Accelerating Its Formation and Promoting Metastasis
Pre-metastatic niche (PMN) formation is a critical step in metastatic progression, yet the biological effect of subtherapeutic-dose of ionizing radiation (SDIR) following radiotherapy on this process remains unclear. Using a 4T1 breast cancer mouse model, we investigated the effects of SDIR (3×0.3 G...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-21 | PXD062108 | Pride
Pre-metastatic niche  subtherapeutic-dose of ionizing radiation  metastasis 
ProteomicsCardiac tissue remodeling as a new marker to predict cardiac dysfunction induced by radiotherapy.
The contribution of radiotherapy, per se, in late cardiotoxicity remains controversial. An experimental model was developed, in which rat hearts were exposed to a range of ionizing radiation doses, to clarify its impact on the development of early cardiac dysfunction. Rat’s hearts were exposed to da...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-09-08 | PXD033194 | Pride
Gls Cardiac tissue Cardiac muscle Cardiooncology Cardiac dysfunction Radiotherapy 
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