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MetabolomicsInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of membrane tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. In contrast, we reveal here a funct...
2021-05-06 | MTBLS2444 | MetaboLights
ProteomicsPex3 promotes formation of peroxisome-peroxisome and peroxisome-lipid droplet contact sites
Peroxisomes are ubiquitous organelles that mediate central metabolic functions, such as fatty acid β-oxidation, as well as diverse tissue- and organism-specific processes. Membrane contact sites, regions of close apposition with other organelles for direct communication, are central to several aspec...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-22 | PXD063514 | Pride
Yeast turboid pex3 contact sites peroxisomes lipid droplets 
ProteomicsIdentification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites
Membrane contact sites are cellular structures that mediate inter-organelle exchange and communication. The endoplasmic reticulum (ER), which forms a network extending throughout the cytoplasm, possesses two known major tether proteins, named VAP-A and VAP-B, that allow its interaction with other or...
ORGANISM(S): Homo sapiens (Human) 
2018-06-05 | PXD009575 | Pride
Endoplasmic reticulum Mospd2 Ffat motif 
UnknownEuropean Surveillance System on Contact Allergies (ESSCA): Contact allergies in relation to body sites in patients with allergic contact dermatitis.
Not available
S-EPMC6590142 | biostudies-literature
ProteomicsProximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites
Membrane contact sites between organelles are critical for transfer of biomolecules. Lipid droplets store fatty acids and form contacts with mitochondria, which regulate fatty acid oxidation and adenosine triphosphate production. Protein compartmentalization at lipid droplet-mitochondria contact sit...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD060912 | Pride
Lipid droplet Fatty acid Lipid metabolism Lipidomics Lipotoxicity Mitochondria Cell metabolism 
ProteomicsProfiling the LAM family of contact-site tethers provides mechanistic insights into their regulation and function
Membrane contact sites are molecular bridges between organelles that are sustained by tethering proteins and enable organelle communication. The endoplasmic reticulum (ER) membrane harbors many distinct families of tether proteins that enable the formation of contacts with all other organelles. One ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051014 | Pride
Membrane contact sites  endoplasmic reticulum  lam protein family  proximity labelling  abolish 
ProteomicsProfiling the LAM family of contact-site tethers provides mechanistic insights into their regulation and function
Membrane contact sites are molecular bridges between organelles that are sustained by tethering proteins and enable organelle communication. The endoplasmic reticulum (ER) membrane harbors many distinct families of tether proteins that enable the formation of contacts with all other organelles. One ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-03-10 | PXD051047 | Pride
Membrane contact sites  endoplasmic reticulum  lam protein family  proximity labelling  abolish 
TranscriptomicsStreptococcus suis 05ZY: control vs contact with hBMEC 3 h
The interactions of Streptocococcus suis (S.suis) with human microvascular endothelial cells (hBMEC) are important process for S.suis passage across human blood brain barrier (BBB). S.suis has evolved precise mechanisms to alter gene expression depending on the distinct challenges posed by particula...
ORGANISM(S): Streptococcus suis 05ZYH33 
2015-12-31 | E-GEOD-46962 | biostudies-arrayexpress
TranscriptomicsStreptococcus suis 05ZY: control vs contact with hBMEC 1 h
The interactions of Streptocococcus suis (S.suis) with human microvascular endothelial cells (hBMEC) are important process for S.suis passage across human blood brain barrier (BBB). S.suis has evolved precise mechanisms to alter gene expression depending on the distinct challenges posed by particula...
ORGANISM(S): Streptococcus suis 05ZYH33 
2015-12-31 | E-GEOD-46961 | biostudies-arrayexpress
ProteomicsContact-ID, a new tool for profiling organelle-membrane contact sites, reveals regulatory proteins of mitochondrial-associated membrane formation
The mitochondria-associated membrane (MAM) has emerged as a cellular signaling hub regulating various cellular processes. However, its molecular components remain unclear owing to lack of reliable methods to purify the intact MAM proteome in a physiological context. Here, we introduce Contact-ID, a ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084362 | MassIVE
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