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MetabolomicsFuzheng Jiedu Xiaoji Formula Enhances Anti-PD-1 Therapy for Hepatocellular Carcinoma by Inhibiting Regulatory T Cell Lipotoxicity

Background: The objective response rate of anti-programmed death receptor 1 (PD-1) immunotherapy in hepatocellular carcinoma (HCC) remains limited. The tumor immunosuppressive microenvironment mediated by regulatory T cells (Tregs) is a key bottleneck. The traditional Chinese medicine (TCM) compo...

2025-12-05 | MTBLS13458 | MetaboLights
MetabolomicsGlobal Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity
Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...
2018-04-26 | MTBLS582 | MetaboLights
ProteomicsDiscovery of lipotoxicity-sensitive transcription factors in non-alcoholic steatohepatitis
Non-alcoholic fatty liver disease is continuum of disorders among which non-alcoholic steatohepatitis (NASH) is particularly associated with a negative prognosis. Hepatocyte lipotoxicity is one of the main pathogenic factors of liver fibrosis and NASH. However, the molecular mechanisms regulating th...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-07-08 | PXD026717 | Pride
Tmt Transcription factor Non-alcoholic steatohepatitis 
GenomicsTranscriptional regulation of liver lipotoxicity in non-alcoholic steatohepatitis [ATAC-seq]
Transcriptional regulation of liver lipotoxicity in non-alcoholic steatohepatitis [ATAC-seq]
PRJNA726930 | ENA
GenomicsTranscriptional regulation of liver lipotoxicity in non-alcoholic steatohepatitis [RNA-seq]
Transcriptional regulation of liver lipotoxicity in non-alcoholic steatohepatitis [RNA-seq]
PRJNA726931 | ENA
TranscriptomicsDifferential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice.
Obesity-associated insulin resistance is characterized by a state of chronic, low-grade inflammation that is associated with the accumulation of M1 proinflammatory macrophages in adipose tissue. Although different evidence explains the mechanisms linking the expansion of adipose tissue and adipose t...
ORGANISM(S): Mus musculus 
2012-03-22 | E-GEOD-36669 | biostudies-arrayexpress
GenomicsPP2Ac knockdown attenuates lipotoxicity-induced pancreatic β-cell dysfunction and apoptosis
PP2Ac knockdown attenuates lipotoxicity-induced pancreatic β-cell dysfunction and apoptosis
PRJNA1013896 | ENA
MetabolomicsHepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on the inflammatory component of the disease, however, recent advances support the notion that sepsis is accompanied by extensive metabolic ...

2020-01-10 | MTBLS1386 | MetaboLights
GenomicsRNASET2 degrades mRNAs that protect against lipotoxicity
RNASET2 degrades mRNAs that protect against lipotoxicity
PRJNA1489459 | ENA
ProteomicsProteomic profiles of INS1 cells
In this study, we obtained proteomic profiles of INS1 cells with lipotoxicity and glucolipotoxicity in a time-course fashion.
ORGANISM(S): Rattus rattus (Black rat) 
2018-08-14 | PXD008154 | Pride
Ins1 lipotoxicity glucolipotoxicity 
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