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ProteomicsLabel-free comparative data dependent (DDA) nanoLC-MS/MS analysis of redox mediated posttranslational modifications (PTMs) in the proteomes from mouse primary dendritic cells (DC) isolated from control B6 and obese (Ob/Ob) mice
Proteomic modifications linked to non-enzymatic glycation and glycoxidation are common in all tissues under hyperglycemic conditions, as present in metabolic syndrome, type 2 diabetes (T2D), mice bearing a homozygous mutation in leptin (so-called Ob/Ob mice, a common model of obesity and T2D) and mi...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-21 | PXD024239 | Pride
Control b6 and ob/ob mice dendritic cells Bottom-up proteomics on qehf and velos orbitrap 
ProteomicsCharacterization of I-Ab MHCII immunopeptidome eluted from control and obese (Ob/Ob) mice using a combination of data-dependent (DDA) and data-independent acquisition (DIA) nanoLC mass spectrometry
In Dendritic cells (DC), the MHC II eluted immunopeptidome reflects the antigenic composition of the microenvironment. Proteins are transported and processed into peptides in endosomal MHC II compartments through autophagy or phagocytosis; extracellular peptides can also directly bind MHC II protein...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-21 | PXD023581 | Pride
Mouse dendritic cells  i-ab mhc-ii immunopeptidome  dda and dia nanolcms 
ProteomicsCharacterization of I-Ab MHCII immunopeptidome eluted from control and obese (Ob/Ob) mice (2)
In Dendritic cells (DC), the MHC II eluted immunopeptidome reflects the antigenic composition of the microenvironment. Proteins are transported and processed into peptides in endosomal MHC II compartments through autophagy or phagocytosis; extracellular peptides can also directly bind MHC II protein...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-21 | PXD018783 | Pride
Mouse i-ab mhcii peptidome  lc/ms/ms dda on qe mass spectrometer 
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