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ProteomicsSystem level analysis of insulin action revels insight into whole body metabolism and insulin action in muscle and adipose tissue
Muscle and adipose tissue insulin resistance are major drivers of metabolic disease. To uncover pathways involved in insulin resistance specifically in these tissues, we leveraged the metabolic diversity of different dietary exposures and discrete inbred mouse strains. This revealed that muscle insu...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-24 | PXD029680 | Pride
Insulin resistance Seven strains Mouse Soleus muscle 
UnknownGenetic variance in the murine defensin locus modulates glucose homeostasis.
Not available
S-EPMC12528722 | biostudies-literature
ProteomicsLeveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance
Systems genetics has begun to tackle the complexity of insulin resistance by capitalising on computational advances to study high-diversity populations. “Diversity Outbred in Australia (DOz)” is a population of genetically unique mice with profound metabolic heterogeneity. We leveraged this variance...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-31 | PXD042277 | Pride
Insulin resistance Skeletal muscle Diversty outbred Mouse 
UnknownLeveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance.
Not available
S-EPMC10371229 | biostudies-literature
UnknownDiscovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.
Not available
S-EPMC5601375 | biostudies-literature
UnknownDiscovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate.
Not available
S-EPMC4018134 | biostudies-literature
UnknownGlecaprevir-pibrentasvir for 4 weeks among people with recent HCV infection: The TARGET3D study.
Not available
S-EPMC10522905 | biostudies-literature
UnknownGenome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.
Not available
S-EPMC5253627 | biostudies-literature
UnknownCasirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8830904 | biostudies-literature
UnknownJoint statement in support of hepatitis C human challenge studies.
Not available
S-EPMC12931952 | biostudies-literature
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