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TranscriptomicsWhole transcriptome profiling of rat pineal glands and retinas collected throughout a 24-hour cycle
The rat pineal transcriptome is highly dynamic, with many hundreds of transcripts changing more than two-fold on a 24-hr basis, as revealed earlier using Affymetrix GeneChip analysis. The retina is evolutionally related to the pineal gland so these two tissues share many gene expression patterns. Th...
ORGANISM(S): Rattus norvegicus 
2014-02-05 | E-GEOD-46069 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome profiling of the rat pineal gland during development from embryonic day 21 to adult
The transcriptome of the rat pineal gland is highly dynamic, with many hundreds of genes changing more than two-fold on a 24-hr daily rhythm, as revealed earlier using Affymetrix GeneChip analysis. Several key transcription factors and enzymes are known to change dramatically during development of t...
ORGANISM(S): Rattus norvegicus 
2014-10-24 | E-GEOD-46127 | biostudies-arrayexpress
TranscriptomicsArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
RELEVANCE: Smith-Lemli-Opitz syndrome (SLOS) is a human disease caused by mutations in the gene coding for the enzyme DHCR7 (7-dehydrocholesterol (7DHC) reductase), which catalyzes the final step of cholesterol biosynthesis. Accumulated 7DHC in tissues and body fluids of SLOS patients gives rise t...
ORGANISM(S): Mus musculus 
2021-03-20 | E-MTAB-10055 | biostudies-arrayexpress
TranscriptomicsSelective knockout of NeuroD1 in the retina and pineal gland
NeuroD1 encodes a basic helix-loop-helix transcription factor involved in the development of neural and endocrine structures. NeuroD1 mRNA is highly abundant in the adult mammalian pineal gland and exhibits a developmental expression pattern similar to the retina. This is consistent with the common ...
ORGANISM(S): Mus musculus 
2012-07-25 | E-GEOD-35396 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse NeuroD1 knockout pineal glands vs 129 wild types at P0
This study determines pineal gland gene expression levels in the NeuroD1 knockout mouse at postnatal day zero. Comparison was performed against pineal gland gene expression levels in 129 wildtype mice also disected at P0. Experiment Overall Design: Wildype 129 mice served as the reference in compari...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6030 | biostudies-arrayexpress
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