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TranscriptomicsTranscription profiling of rat normal (control) and diabetic animals left ventricle heart tissue
Analysis of gene expression changes in the LV of a rodent heart that occur with uncontrolled diabetes; We used microarrays to detail the global changes that occur in gene expression in the LV of the heart as a result of STZ-induced diabetes. Experiment Overall Design: Male wistars were anaesthetised...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5606 | biostudies-arrayexpress
TranscriptomicsThe long non-coding RNA Paupar regulates the expression of both local and distal genes [CHART-seq]
Although some long noncoding RNAs (lncRNAs) have been shown to regulate gene expression in cis, it remains unclear whether lncRNAs can directly regulate transcription in trans by interacting with chromatin genome-wide independently of their sites of synthesis. Here, we describe the genomically local...
ORGANISM(S): Mus musculus 
2013-11-21 | E-GEOD-52570 | biostudies-arrayexpress
UnknownIncreased phosphorylation of HexM improves lysosomal uptake and potential for managing GM2 gangliosidoses.
Not available
S-EPMC10074939 | biostudies-literature
UnknownFamotidine Use Is Not Associated With 30-day Mortality: A Coarsened Exact Match Study in 7158 Hospitalized Patients With Coronavirus Disease 2019 From a Large Healthcare System.
Not available
S-EPMC7550093 | biostudies-literature
GenomicsFunctional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ES cells
The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular organisms. Here we characterize AEBP2, a known PRC2 cofactor which, in vitro, has been shown to stimulate PRC2 activity. We show that AEBP2 localises specifically to PRC2 target loci, incl...
ORGANISM(S): Mus musculus 
2016-08-02 | E-GEOD-83082 | biostudies-arrayexpress
UnknownThe attenuated hepatic clearance of propionate increases cardiac oxidative stress in propionic acidemia.
Not available
S-EPMC11702364 | biostudies-literature
Genomicsproj022_chipseq
The mechanisms that recruit the major Polycomb-group (PcG) complexes PRC1 and PRC2 to target sites in vertebrate cells are not well understood. Building on recent studies that have determined a reciprocal relationship between DNA methylation and Polycomb activity, we demonstrate that in methylation ...
ORGANISM(S): Mus musculus 
2014-05-23 | E-MTAB-2481 | biostudies-arrayexpress
UnknownMAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial.
Not available
S-EPMC11704051 | biostudies-literature
UnknownPrevalence of propionic acidemia in China.
Not available
S-EPMC10493020 | biostudies-literature
GenomicsEGAS00001000262-sc-20131030 - samples
Whole genome DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of 3 men. For each of three different prostates, multiple tumour samples (4, 5, and 3 depending on the case) and one normal tissu...
EGAD00001000689 | EGA
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