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ProteomicsCryo-EM structure of the human COP1-DET1 ubiquitin ligase complex
Ubiquitin modification regulates fundamental cellular processes by controlling protein stability and function. The ubiquitin ligase COP1, conserved from plants to humans, targets developmental transcription factors. COP1 can act on its own or be incorporated into CULLIN4–RING ligase (CRL4) complexes...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD071633 | Pride
Human Cop1-det1 ubiquitin ligase Cx-ms 
UnknownCryo-EM structure of the human COP1-DET1 ubiquitin ligase complex.
Not available
S-EPMC12808801 | biostudies-literature
UnknownDET1 dynamics underlie cooperative ubiquitination by CRL4<sup>DET1-COP1</sup> complexes.
Not available
S-EPMC11864197 | biostudies-literature
GenomicsDET1-mediated COP1 regulation avoids HY5 activity over second-site targets to tune plant photomorphogenesis
DE-ETIOLATED1 (DET1) is a negative regulator of plant photomorphogenesis acting as a component of the C3D complex, which can further associate to CULLIN4 to form a CRL4C3D E3 ubiquitin ligase. CRL4C3D is thought to act together with CRL4COP1SPA ubiquitin ligase, to promote the ubiquitin-mediated deg...
ORGANISM(S): Arabidopsis thaliana 
2021-09-09 | GSE155147 | GEO
GenomicsDET1-mediated COP1 regulation avoids HY5 activity over second-site targets to tune plant photomorphogenesis
DET1-mediated COP1 regulation avoids HY5 activity over second-site targets to tune plant photomorphogenesis
PRJNA648851 | ENA
UnknownMutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation.
Not available
S-EPMC4914304 | biostudies-literature
UnknownGenetic interactions of Arabidopsis thaliana damaged DNA binding protein 1B (DDB1B) with DDB1A, DET1, and COP1.
Not available
S-EPMC3583456 | biostudies-literature
TranscriptomicsInactivation of DET1 causes neurological defects and lethality in mice and humans II
COP1 and DET1 are components of an E3 ubiquitin ligase that is conserved from plants to humans. Mammalian COP1 binds to DET1 and is a substrate adaptor for the CUL4A-DDB1-RBX1 RING E3 ligase. Its transcription factor substrates, including c-Jun, ETV4, and ETV5, are targeted for proteasomal degradati...
ORGANISM(S): Homo sapiens 
2025-01-28 | GSE271767 | GEO
TranscriptomicsInactivation of DET1 causes neurological defects and lethality in mice and humans I
COP1 and DET1 are components of an E3 ubiquitin ligase that is conserved from plants to humans. Mammalian COP1 binds to DET1 and is a substrate adaptor for the CUL4A-DDB1-RBX1 RING E3 ligase. Its transcription factor substrates, including c-Jun, ETV4, and ETV5, are targeted for proteasomal degradati...
ORGANISM(S): Homo sapiens 
2025-01-28 | GSE271764 | GEO
UnknownUbiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain.
Not available
S-EPMC6217379 | biostudies-literature
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