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TranscriptomicsCrebA is a major and direct regulator of secretory pathway gene expression
Abstract: Secretion occurs in all cells, with relatively low levels in most cells and extremely high levels in specialized secretory cells, such as those of the pancreas, salivary and mammary glands. Here, we report that the CrebA/Creb3-like family of bZip transcription factors functions to upregul...
ORGANISM(S): Drosophila melanogaster 
2010-10-18 | E-GEOD-23346 | biostudies-arrayexpress
TranscriptomicsGene regulated by ectopic expression of Sage in the entire Drosophila embryo
FoxA transcription factors play major roles in organ-specific gene expression. How FoxA proteins achieve specificity is unclear, given their broad expression patterns and requirements in multiple cell types. Here, we characterize Sage, a basic helix-loop-helix (bHLH) transcription factor expressed e...
ORGANISM(S): Drosophila melanogaster 
2013-06-06 | E-GEOD-40358 | biostudies-arrayexpress
TranscriptomicsTrachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis
Abstract: The Drosophila trachea is a branched tubular epithelia that transports oxygen and other gases. trachealess (trh), which encodes a bHLH-PAS transcription factor, is among the first genes to be expressed in the cells that will form the trachea. In the absence of trh, tracheal cells fail to i...
ORGANISM(S): Drosophila melanogaster 
2011-12-21 | E-GEOD-28780 | biostudies-arrayexpress
TranscriptomicsGene expression data from wild-type (WT) and ribbon (rib) mutant Drosophila mid through late stage embryos
Transcription factors, which regulate the spatiotemporal patterns of gene expression during organogenesis, often regulate multiple aspects of tissue morphogenesis, including cell-type specification, cell proliferation, cell death, cell polarity, cell shape, cell arrangement and cell migration. In th...
ORGANISM(S): Drosophila melanogaster 
2015-12-21 | E-GEOD-72598 | biostudies-arrayexpress
TranscriptomicsThe CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity
Abstract: Secretion occurs in all cells, with relatively low levels in most cells and extremely high levels in specialized secretory cells, such as those of the pancreas, salivary and mammary glands. Here, we report that the CrebA/Creb3-like family of bZip transcription factors functions to upregul...
ORGANISM(S): Homo sapiens 
2010-10-18 | E-GEOD-23349 | biostudies-arrayexpress
TranscriptomicsGenes regulated by ectopic expression of Sage in the entire Drosophila embryo using RNA from tub-Gal4 embryos.
FoxA transcription factors play major roles in organ-specific gene expression. How FoxA proteins achieve specificity is unclear, given their broad expression patterns and requirements in multiple cell types. Here, we characterize Sage, a basic helix-loop-helix (bHLH) transcription factor expressed e...
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-44090 | biostudies-arrayexpress
TranscriptomicsFork head targets in Stage 11 Drosophila embryos
Transcription factors drive organogenesis, from the initiation of cell fate decisions to the maintenance and implementation of these decisions. The Drosophila embryonic salivary gland provides an excellent platform for unraveling the underlying transcriptional networks of organ development because D...
ORGANISM(S): Drosophila melanogaster 
2011-12-31 | E-GEOD-28324 | biostudies-arrayexpress
TranscriptomicsTargets of the bHLH transcription factor, Sage
FoxA transcription factors play major roles in organ-specific gene expression. How FoxA proteins achieve specificity is unclear, given their broad expression patterns and requirements in multiple cell types. Here, we characterize Sage, a basic helix-loop-helix (bHLH) transcription factor expressed e...
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-40963 | biostudies-arrayexpress
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