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TranscriptomicsA new structural paradigm in copper resistance in a human pathogen
Copper is essential for both innate and adaptive immune function and copper resistance has emerged as an important determinant of virulence of microbial pathogens. In the human pathogen Streptococcus pneumoniae (Spn), cytoplasmic copper resistance is mediated by an operon encoding the copper-respons...
ORGANISM(S): Streptococcus pneumoniae 
2013-05-24 | E-GEOD-39176 | biostudies-arrayexpress
ProteomicsQuantitative mapping of methionine sensitivity to oxidation in the two-copper chaperone PcuC from Cereibacter sphaeroides
Copper is typically coordinated by histidine, cysteine, or methionine residues in enzyme or chaperones and these residues are particularly sensitive to oxidation. However, it remains unclear whether copper-coordinating residues exhibit different sensitivity to oxidation compared to their non-coordin...
ORGANISM(S): Cereibacter sphaeroides Bacteria 
2026-02-09 | PXD062219 | Pride
Methionine oxidation Cofactor biosynthesis Periplasm Copper chaperone Oxaziridine 
TranscriptomicsSystems analysis of Chlamydomonas Cu nutrition reveals connections between Cu and multiple O2-dependent metabolic steps
We used digital gene expression (NlaIII sequence tags) and RNA-Seq to compare the transcriptomes of Cu-replete vs. Cu–deficient Chlamydomonas wild-type cells to reveal dozens of mRNAs whose abundance is modified. Half of the corresponding genes are targets of CRR1, a master regulator of nutritional ...
ORGANISM(S): Chlamydomonas reinhardtii 
2011-10-23 | E-GEOD-25124 | biostudies-arrayexpress
TranscriptomicsCopper-regulated genes of Bradyrhizobium japonicum
Copper-limiting growth conditions were thought to cause an induction of genes possibly involved in copper uptake and sorting. This rationale in mind, we performed microarray analyses on B. japonicum cells grown in three variations of the BVM minimal medium. Variant 1 contained 2 M-NM-
ORGANISM(S): Bradyrhizobium japonicum 
2012-10-01 | E-GEOD-40437 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response of genes involved in cell cycle regulation are effected by the deletion of ATX1 encoding the copper chaperone
In this study, genome-wide effect of the absence of ATX1 gene was investigated under copper deficient and high copper (0.5 mM) conditions in comparsion to the reference strain (data for the reference strain is derived from E-MTAB_. For this purpose, ATX1 deleted cells were cultivated in fully contro...
ORGANISM(S): Saccharomyces cerevisiae 
2016-06-10 | E-MTAB-4230 | biostudies-arrayexpress
ProteomicsCOPPER INDUCES PROTEIN AGGREGATION, A TOXIC PROCESS COMPENSATED BY MOLECULAR CHAPERONES.
Copper is a powerful antimicrobial and antiviral agent, which has interest through several biomedical applications. Nevertheless, how copper induces the cellular damage is not fully understood. Two main mechanisms are claimed to be involved, i.e. Cu catalyzed reactive oxygen species production (ROS...
ORGANISM(S): Escherichia coli 
2022-02-10 | PXD019288 | Pride
Hsp33 Escherichia coli Molecular chaperone Copper Aggregation 
TranscriptomicsDifferential expression analysis of T. thermophilus HB8 csoR deficient strain in response to copper.
We observed the expression profile of the total mRNA in Thermus thermophilus HB8 csrR deficient strain at 0 and 30 min after the addition of CuSO4. Three csoR deficient strain of T. thermophilus HB8 were pre-cultured at 70 degC for 16 hours in 3 mL of TT medium containing 0.8% polypeptone, 0.4% yeas...
ORGANISM(S): Thermus thermophilus HB8 
2010-04-13 | E-GEOD-19509 | biostudies-arrayexpress
TranscriptomicsDifferential expression analysis of T. thermophilus HB8 wild-type strain in response to copper.
We observed the expression profile of the total mRNA in Thermus thermophilus HB8 wild-type strain at 0 and 30 min after the addition of CuSO4. Three wild-type strain of T. thermophilus HB8 were pre-cultured at 70 degC for 16 hours in 3 mL of TT medium containing 0.8% polypeptone, 0.4% yeast extract,...
ORGANISM(S): Thermus thermophilus HB8 
2010-04-13 | E-GEOD-19508 | biostudies-arrayexpress
UnknownGenomic organization of ATOX1, a human copper chaperone.
Not available
S-EPMC150598 | biostudies-literature
UnknownStructure and dimerization properties of the plant-specific copper chaperone CCH.
Not available
S-EPMC11330527 | biostudies-literature
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