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TranscriptomicsThe Arabidopsis copper transport protein COPT2 and the responses under copper and iron deficiency.
Copper and iron are essential micronutrients for most living organisms because they participate as cofactors in biological processes including respiration, photosynthesis and oxidative stress protection. In many eukaryotic organisms, including yeast and mammals, copper and iron homeostases are highl...
ORGANISM(S): Arabidopsis thaliana 
2013-06-05 | E-GEOD-42642 | biostudies-arrayexpress
TranscriptomicsTRANSCRIPTIONAL REMODELLING IN RESPONSE TO CHANGING COPPER LEVELS IN WILSON DISEASE MODEL OF SACCHAROMYCES CEREVISIAE
A 3 x 2 factorial design was used to elucidate the genome-wide transcriptional response to the deletion of yeast ortholog of Wilson and Menkes disease causing gene; CCC2, at changing copper levels. Homozygous deletion mutant of CCC2, which encodes Cu+2 transporting P-type ATPase required to export c...
ORGANISM(S): Saccharomyces cerevisiae 
2013-09-02 | E-MEXP-3927 | biostudies-arrayexpress
TranscriptomicsZinc deficiency impacts CO2 assimilation and disrupts copper homeostasis in Chlamydomonas reinhardtii
Zinc is an essential nutrient because of its role in catalysis and in stabilizing protein structure, but excess zinc can also be deleterious. Four nutritional zinc states have been identified in the alga Chlamydomonas reinhardtii: zinc toxic, zinc replete, zinc deficient and zinc limited. Growth is ...
ORGANISM(S): Chlamydomonas reinhardtii 
2013-05-03 | E-GEOD-41096 | biostudies-arrayexpress
ProteomicsAdaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
Rare inherited diseases caused by mutations in the copper transporters SLC31A1 (CTR1) or ATP7A induce copper deficiency in the brain, causing seizures and neurodegeneration in infancy through poorly understood mechanisms. Here, we used multiple model systems to characterize the molecular mechanisms ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059097 | Pride
Tmt Neurodegeneration Mtor 
TranscriptomicsRNA-seq of Arabidopsis spl7 identifies two genes required for copper acquisition and a copper dependence of iron homeostasis
The transition metal copper (Cu) is an essential element for all living organisms. In plants, Cu plays key roles in electron transport chains of chloroplasts and mitochondria, as well as in cell wall metabolism, ethylene perception, molybdenum cofactor synthesis and oxidative stress protection. Beca...
ORGANISM(S): Arabidopsis thaliana 
2013-10-14 | E-GEOD-24696 | biostudies-arrayexpress
TranscriptomicsThe Arabidopsis copper transport protein COPT2 and the responses under copper and iron deficiency.
Copper and iron are essential micronutrients for most living organisms because they participate as cofactors in biological processes including respiration, photosynthesis and oxidative stress protection. In many eukaryotic organisms, including yeast and mammals, copper and iron homeostases are highl...
ORGANISM(S): Arabidopsis thaliana 
2013-06-05 | GSE42642 | GEO
ProteomicsComparison of proteomic responses to individual and combinatorial copper and iron deficiencies in Arabidopsis thaliana rosettes.
Purpose: plants exposed to multiple simultaneous adverse growth conditions trigger molecular responses that differ from the sum of those to individual stressors. Copper and iron are fundamental elements required for proper photosynthesis, energy production, DNA metabolism and hormone sensing, among ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-06-22 | PXD013598 | Pride
Abiotic stress Combinatorial stress Iron Systems biology Proteomics. Copper 
GenomicsEffect of Copper deficiency on gene expression of Lin-c-Kit cell in the bone marrow of mice
Effect of Copper deficiency on gene expression of Lin-c-Kit cell in the bone marrow of mice
PRJNA1152929 | ENA
GenomicsEnergy status-promoted growth and development of Arabidopsis require copper deficiency response transcriptional regulator SPL7
Energy status-promoted growth and development of Arabidopsis require copper deficiency response transcriptional regulator SPL7
PRJEB47134 | ENA
TranscriptomicsEffect of Copper deficiency on gene expression of Lin-c-Kit cell in the bone marrow of mice
Copper homeostasis has been linked to human health and hematopoiesis. However, the underlying mechanisms remain elusive. Here, we demonstrate the pivotal role of the transporter Slc31a1(Ctr1) in copper uptake, during postnatal hematopoiesis. Specifically, Slc31a1-mediated copper transport sustains t...
ORGANISM(S): Mus musculus 
2025-12-31 | GSE275760 | GEO
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