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TranscriptomicsTranscriptome analysis reveals molecular profiles associated with evolving steps of monoclonal gammopathies
To gain further insights into the role of the transcriptome deregulation in the transition from a normal plasma cell (NPC) to a clonal PC and from an indolent clonal PC to a malignant PC, we performed gene expression profiling in 20 patients with MGUS, 33 with high-risk SMM and 41 with MM. The analy...
ORGANISM(S): Homo sapiens 
2014-05-22 | E-GEOD-47552 | biostudies-arrayexpress
TranscriptomicsPhenotypic, transcriptomic and genomic characterization of clonal plasma cells in light chain amyloidosis [Gene expression profiling]
Immunoglobulin light-chain amyloidosis (AL) is a rare clonal plasma cell (PC) disorder that remains largely incurable. AL and multiple myeloma (MM) share the same cellular origin, but while knowledge about MM PC biology has improved significantly, the same does not apply for AL. Here, we undertook a...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-73040 | biostudies-arrayexpress
TranscriptomicsThe cellular origin and malignant transformation of Waldenström's Macroglobulinemia [gene expression]
Although information on the molecular pathogenesis of Waldenström’s Macroglobulinemia (WM) has greatly improved in recent years, the exact cellular origin and the mechanisms behind WM transformation from IgM MGUS remain undetermined. Here, we undertook an integrative phenotypic, molecular and genomi...
ORGANISM(S): Homo sapiens 
2015-05-05 | E-GEOD-61597 | biostudies-arrayexpress
TranscriptomicsPhenotypic, transcriptomic and genomic characterization of clonal plasma cells in light chain amyloidosis [Copy number analysis]
Immunoglobulin light-chain amyloidosis (AL) is a rare clonal plasma cell (PC) disorder that remains largely incurable. AL and multiple myeloma (MM) share the same cellular origin, but while knowledge about MM PC biology has improved significantly, the same does not apply for AL. Here, we undertook a...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-73041 | biostudies-arrayexpress
TranscriptomicsThe cellular origin and malignant transformation of Waldenström's Macroglobulinemia [copy number variation]
Although information on the molecular pathogenesis of Waldenström’s Macroglobulinemia (WM) has greatly improved in recent years, the exact cellular origin and the mechanisms behind WM transformation from IgM MGUS remain undetermined. Here, we undertook an integrative phenotypic, molecular and genomi...
ORGANISM(S): Homo sapiens 
2015-05-06 | E-GEOD-61650 | biostudies-arrayexpress
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