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TranscriptomicsTranscription profiling of mouse murine dorsal neural tube bisected along the midline with one half from each embryo used for control and the other half treated with 10-6M RA dissolved in ethanol for 6, 12, 24 or 48 h
This series represents murine dorsal neural tube bisected along the midline with one half from each embryo used for control and the other half treated with 10-6M RA dissolved in ethanol for 6, 12, 24 or 48 h. For 6 h exposures, the explants were cultured overnight on fibronectin coated 35mm dishes (...
ORGANISM(S): Mus musculus 
2007-10-11 | E-GEOD-1588 | biostudies-arrayexpress
TranscriptomicsVitamin A nutritional status and retinoic acid as regulators of gene expression in rat liver
Vitamin A (retinol) is an essential precursor for the production of retinoic acid (RA), which in turn is a major regulator of gene expression, affecting cell differentiation throughout the body. Understanding how vitamin A nutritional status, as well as therapeutic retinoid treatment, regulates the ...
ORGANISM(S): Rattus norvegicus 
2011-08-31 | E-GEOD-24104 | biostudies-arrayexpress
TranscriptomicsRelocalization of retinoic acid receptors from non-canonical to canonical spaced binding elements during embryoid body differentiation
Retinoic Acid Receptors (RARs) bind RA-response elements in regulatory regions of their target genes. While canonical RAREs comprise direct repeats of the consensus 5’-RGKTCA-3’ sequence separated by 1, 2 or 5 nucleotides (DR1, DR2, DR5), we show that shortly after RA treatement of mouse embryoid bo...
ORGANISM(S): Mus musculus 
2012-06-15 | E-GEOD-35599 | biostudies-arrayexpress
TranscriptomicsmRNA profile in purified human peripheral blood eosinophil treated with retinoic acids
Objectives: Eosinophils cultured with all-trans RA (ATRA) and 9-cis RA showed dramatically induced cell survival, and the efficacy of RAs (10-6 M) was similar to that of IL-5 (1 ng/ml), the most critical cytokine for eosinophil activation. Using a gene microarray, we studied mRNA profile regulated ...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-12926 | biostudies-arrayexpress
ProteomicsGonatopoulos-Pournatzis _eIF4Gmicroexon_P105_Lumos
A This dataset consists of 24 raw MS files, acquired on Orbitrap Fusion Lumos Tribrid mass spectrometer operated in Data Dependent Acquisition mode. B Mouse samples were generated by Thomas Gonatopoulos-Pournatzis. Proteomics sample preparation and mass spectrometric acquisition was performed by Sh...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-12-04 | MSV000084658 | MassIVE
GenomicsDissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics [ChIP-seq]
Retinoic acid (RA) triggers physiological processes by activating heterodimeric transcription factors comprising retinoic acid (RARa,b,g) and retinoid X (RXRa,b,g) receptors. How a single signal induces highly complex temporally controlled networks that ultimately orchestrate physiological processes...
ORGANISM(S): Mus musculus 
2011-10-11 | E-GEOD-30538 | biostudies-arrayexpress
ProteomicsGas-phase stability and thermodynamics of ligand-bound, binary complexes of chloramphenicol acetyltransferase reveal negative cooperativity
Bottom-up proteomics confirms the identity of protein at EcCATI.
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2023-04-04 | MSV000091635 | MassIVE
UnknownTesting the depth-differentiation hypothesis in a deepwater octocoral.
Not available
S-EPMC4424640 | biostudies-literature
TranscriptomicsTranscription profiling of human AML cell line OCI/AML2 treated with valproic acis and all trans retinoic acid
Purpose: Treatment of acute promyelocytic leukemia (APL) with the retinoid, all trans retinoic acid (ATRA), along with standard chemotherapy has significantly improved survival compared to chemotherapy alone1. ATRA mediates its benefit in APL by overcoming the transcriptional block mediated by PML-R...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2668 | biostudies-arrayexpress
TranscriptomicsEffects of vitamin A on Ventricular myocardium gene expression [right ventricle]
LRAT knockout mice on vitamin A sufficient or deficient diets were compared to age-matched wild type mice on a vitamin A sufficient diet RNA was isolated from right ventricle of the heart and one array was run for each sample.
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-74905 | biostudies-arrayexpress
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