Vitamin A nutritional status and retinoic acid as regulators of gene expression in rat liver

ABSTRACT: Vitamin A (retinol) is an essential precursor for the production of retinoic acid (RA), which in turn is a major regulator of gene expression, affecting cell differentiation throughout the body. Understanding how vitamin A nutritional status, as well as therapeutic retinoid treatment, regulates the expression of retinoid homeostatic genes is important for improving dietary recommendations and therapeutic strategies using retinoids. This study investigated genes central to processes of retinoid uptake and storage, release to plasma, and oxidation in the liver of rats under steady-state conditions after different exposures to dietary vitamin A (deficient, marginal, adequate and supplemented), and acutely after administration of a therapeutic dose of all-trans-RA. Over a very wide range of di

ORGANISM(S): Rattus norvegicus

SUBMITTER: A. Ross 

PROVIDER: E-GEOD-24104 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress