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TranscriptomicsExpression data from Docetaxel-resistant prostate cancer cells
Docetaxel is the standard first line therapy for hormone-refractory prostate cancer patients. Here we generated models of Docetaxel resistance in prostate cancer cells to study the molecular pathways that drive the acquisition of resistance to this therapy. We used microarrays to detail the global p...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-36135 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression in lymphoma lines
MicroRNAs from lymphoma and leukemia cell lines with or without the 13q31 amplicon were quantitated using a custom microarray platform. 5ug total RNA from each line was labeled with cy3 and hybridized to a microarray that contains probes to 238 mouse and human mature microRNAs. Four data sets per ...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-2399 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human gamma-secretase inhibitor-sensitive and -resistant T-ALL cell lines
Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias making this receptor a promising target for drugs such as gamma-secretase inhibitors, which block a proteolytic cleavage required for NOTCH1 activation. However, the enthusiasm for these therapies has been tempered by ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5682 | biostudies-arrayexpress
UnknownAnticoagulation, Bleeding, Mortality, and Pathology in Hospitalized Patients With COVID-19.
Not available
S-EPMC7449655 | biostudies-literature
TranscriptomicsExpression data from isogenic Pten WT mouse T-ALLs infected with MSCV Myr-AKT-IRES-mCherry or empty vector, treated with DBZ or DMSO
To explore the mechanisms downstream of NOTCH1 and PTEN in the control of leukemia cell growth, we performed expression profiling on NOTCH1 induced and Pten-positive T-ALL tumor cells infected with constitutively active AKT (myristoylated-AKT). Constitutive activation of AKT rescues the transcriptio...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71089 | biostudies-arrayexpress
UnknownThe metabolic co-regulator PGC1α suppresses prostate cancer metastasis.
Not available
S-EPMC4884178 | biostudies-literature
TranscriptomicsExpression data from isogenic Pten WT or KO mouse T-ALLs treated with DBZ or DMSO
To investigate the underlying mechanisms mediating resistance to NOTCH inhibition in Pten-null T-ALL tumor cells we performed gene expression profiling of isogenic Pten-positive and Pten-deleted leukemia lymphoblasts after acute treatment with DBZ in vivo. This analysis revealed that, while direct N...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71087 | biostudies-arrayexpress
TranscriptomicsIdentification of PHLPP1 as a tumor suppressor reveals the role of feedback compensation in PTEN-mutant prostate cancer progression
Hyper-activation of the PI 3-Kinase/ AKT pathway is a driving force of many cancers. Here we identify the AKT-inactivating phosphatase PHLPP1 as a prostate tumor suppressor. We show that Phlpp1-loss causes neoplasia and, upon partial Pten-loss, carcinoma in mouse prostate. This genetic setting initi...
ORGANISM(S): Mus musculus 
2011-08-16 | E-GEOD-30987 | biostudies-arrayexpress
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