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GenomicsCore transcriptional regulatory circuit controlled by the tal1 complex in human t-cell acute lymphoblastic leukemia (Subseries)
The oncogenic transcription factor TAL1/SCL is aberrantly overexpressed in over 40% of cases of T-cell acute lymphoblastic leukemia (T-ALL), emphasizing the importance of the TAL1-regulated transcriptional program in the molecular pathogenesis of T-ALL. Here we identify the core transcriptional regu...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-33850 | biostudies-arrayexpress
ProteomicsASCL1: a pioneer factor that induces subtype switching and characterizes adrenergic neuroblastoma
Neuroblastoma is an embryonic malignancy originating from early nerve cells. Neuroblastoma retains plasticity, interconverting between the mesenchymal (MES) and adrenergic (ADRN) states, which are controlled by different sets of transcription factors forming the core regulatory circuit (CRC). Howeve...
ORGANISM(S): Homo sapiens (Human) 
2023-12-08 | PXD037670 | Pride
Ascl1 Subtype switching Neuroblastoma Pioneer factor Core regulatory circuit 
GenomicsCore transcriptional regulatory circuit controlled by the TAL1 complex in human T-cell acute lymphoblastic leukemia
This SuperSeries is composed of the following subset Series: GSE29179: Identification of differentially expressed genes upon shRNA knockdown of TAL1 and its regulatory partners in T-ALL cells (Jurkat) GSE29180: ChIP-Seq of TAL1 and its regulatory partners in T-ALL cells (Jurkat) GSE33850: Core trans...
ORGANISM(S): Homo sapiens 
2012-08-16 | E-GEOD-29181 | biostudies-arrayexpress
GenomicsEWS-FLI1-regulated Core Transcriptional Regulatory Circuit promotes Ewing sarcoma progression
EWS-FLI1-regulated Core Transcriptional Regulatory Circuit promotes Ewing sarcoma progression
PRJNA593608 | ENA
GenomicsIdentification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses
This SuperSeries is composed of the following subset Series: GSE36241: Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (ChIP-Seq) GSE37051: Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (expression) Ref...
ORGANISM(S): Mus musculus 
2012-09-19 | E-GEOD-37052 | biostudies-arrayexpress
GenomicsSynergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit. [ChIP-Seq]
Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit. [ChIP-Seq]
PRJNA1530389 | ENA
GenomicsSynergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit. [Cut & Run]
Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit. [Cut & Run]
PRJNA1530378 | ENA
GenomicsSynergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit [ATAC-seq]
Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit [ATAC-seq]
PRJNA1321725 | ENA
GenomicsSynergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit [ChIP-Seq]
Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit [ChIP-Seq]
PRJNA1321730 | ENA
GenomicsSynergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit [RNA-seq]
Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit [RNA-seq]
PRJNA1321732 | ENA
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