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TranscriptomicsDNA-targeted platinum-acridine anticancer agents
Yeast homozygous and essential heterozygous deletion mutants were screened against novel platinum-containing compounds
ORGANISM(S): Schizosaccharomyces pombe 
2012-08-28 | E-MTAB-1267 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast homozygous and essential heterozygous diploid deletion strains screened with 3-nitroso-imidazo[1,2-a]pyridines and -pyrimidines to identify gene deletions that confer sensitivity to each compound
The complete pool of barcoded homozygous and essential heterozygous diploid deletion strains of S. cerevisiae were screened with 3-nitroso-imidazo[1,2-a]pyridines and -pyrimidines to identify gene deletions that confer sensitivity to each compound.
ORGANISM(S): Saccharomyces cerevisiae 
2008-09-19 | E-TABM-560 | biostudies-arrayexpress
TranscriptomicsHaploinsufficiency profiling by array of yeast heterozygous transposon disruption mutants grown in the presence of different synthetic compounds
A pool of 3633 tagged heterozygous transposon disruption mutants underwent haploinsufficiency profiling in the presence of different synthetic compounds to identify their cellular targets
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-30 | E-MTAB-398 | biostudies-arrayexpress
TranscriptomicsStrain abundance assay of 3633 Candida albicans heterozygous transposon disruption mutants grown in YPD, SC, YNB or SLAD media
A pool of 3633 tagged heterozygous transposon disruption mutants underwent haploinsufficiency profiling in different media conditions (YPD, SC, YNB, and SLAD) to identify slow growing strains in these conditions.
ORGANISM(S): Candida albicans 
2011-09-30 | E-TABM-1080 | biostudies-arrayexpress
TranscriptomicsSRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
The neuroendocrine (NE) phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the NE phenotype in CRPC. Expression of chromogranin A (CHGA), synaptophysin (SYP), androgen receptor (AR), and ...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-66187 | biostudies-arrayexpress
Genomics293_hORF3.1_drug_treatments_partIII
The human ORFeome collection version 3.1 was stably integrated into HEK293 (lentivirus based). The cells harboring the collection were harvested, collection specific DNA was amplified and sequenced to assess the collection representation.
ORGANISM(S): Homo sapiens 
2014-05-15 | E-MTAB-2498 | biostudies-arrayexpress
TranscriptomicsA Characterization of Osteoblastic and Osteolytic Proteins in Prostate Cancer Bone Metastases
Our goal was to determine whether previously identified and novel proteins are associated with the osteoblastic or osteolytic response in clinical specimens of PCa bone metastases. Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used to profile 14 PCa metastases fro...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-41619 | biostudies-arrayexpress
TranscriptomicsTMPRSS2 Influences Prostate Cancer Metastasis
TMPRSS2 is an androgen-regulated cell surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastasis. Through the generation of mouse models with a targeted deletion ...
ORGANISM(S): Mus musculus 
2014-09-09 | E-GEOD-58822 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of yeast heterozygous diploid deletions strains screened with 20 compounds to identify gene deletions that confer sensitivity to each compound
The complete pool of barcoded essential heterozygous diploid deletion strains of S. cerevisiae were screened with 20 compounds from the Chembridge NOVACore chemical library to identify gene deletions that confer sensitivity to each compound.
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-13 | E-TABM-977 | biostudies-arrayexpress
TranscriptomicsMultiple means to the same end: The genetic basis of acquired stress resistance in yeast
A series of experiments comparing the gene expression response before and after 30 min 0.7M NaCl exposure in WT and mutant yeast strains. Mutant strains were identified as having a defect in acquiring resistance to H2O2 following mild NaCl pretreatment. The mutants in this study were taken from the ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-06 | E-GEOD-27819 | biostudies-arrayexpress
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