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ProteomicsNigericin induced paraptosis-like cell death instead of pyroptosis in corneal keratocytes
Corneal wound healing involves complex cellular processes, including keratocyte cell death, which plays a pivotal role in initiating tissue repair. Recent studies suggest that pyroptosis, characterized by the release of pro-inflammatory factors, occurs during tissue repair which may also contribute ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD058468 | Pride
Proteomics Corneal keratocytes Nigericin 
TranscriptomicsTranscription profiling of mouse primary cultures from mouse cornea vs those of the adult and 10-day postnatal mouse cornea to elucidate biological processes underlying the keratocyte, fibroblast, and myofibroblast phenotypes of corneal stromal cells
To elucidate biological processes underlying the keratocyte, fibroblast, and myofibroblast phenotypes of corneal stromal cells, the gene expression patterns of these primary cultures from mouse cornea were compared with those of the adult and 10-day postnatal mouse cornea.
ORGANISM(S): Mus musculus 
2007-10-31 | E-GEOD-1867 | biostudies-arrayexpress
GenomicsCorneal keratocytes, fibroblasts, and myofibroblasts exhibit distinct transcriptional profiles in vitro
Corneal keratocytes, fibroblasts, and myofibroblasts exhibit distinct transcriptional profiles in vitro
PRJNA1215274 | ENA
GenomicsComprehensive analysis of differentially expressed genes responsed to mechanical stretch in human corneal keratocytes.
Comprehensive analysis of differentially expressed genes responsed to mechanical stretch in human corneal keratocytes.
PRJNA510829 | ENA
TranscriptomicsCorneal keratocytes, fibroblasts, and myofibroblasts exhibit distinct transcriptional profiles in vitro
After stromal injury to the cornea, the release of growth factors and pro-inflammatory cytokines promotes the activation of quiescent keratocytes into a migratory fibroblast and/or fibrotic myofibroblast phenotype. Persistence of the myofibroblast phenotype can lead to corneal fibrosis and scarring,...
ORGANISM(S): Oryctolagus cuniculus 
2025-02-21 | GSE287915 | GEO
UnknownCombined Therapy Using Human Corneal Stromal Stem Cells and Quiescent Keratocytes to Prevent Corneal Scarring after Injury.
Not available
S-EPMC9267074 | biostudies-literature
TranscriptomicsComprehensive analysis of differentially expressed genes responsed to mechanical stretch in human corneal keratocytes.
Mechanical stimulation is an important factor for the development of complications after LASIK, but the molecular mechanism still remains unclear. In this study, we have employed whole genome microarray expression profiling as a discovery platform to identify genes responded to mechanical stretch in...
ORGANISM(S): Homo sapiens 
2020-12-31 | GSE124138 | GEO
UnknownEffect of acacia honey on cultured rabbit corneal keratocytes.
Not available
S-EPMC4038055 | biostudies-literature
UnknownNotch1 signaling in keratocytes maintains corneal transparency by suppressing VEGF expression.
Not available
S-EPMC9214072 | biostudies-literature
UnknownCorneal Keratocytes, Fibroblasts, and Myofibroblasts Exhibit Distinct Transcriptional Profiles In Vitro.
Not available
S-EPMC11918030 | biostudies-literature
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