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ProteomicsNigericin-Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis
Innate immune signaling relies on phosphorylation cascades for effective responses. While TLR4 stimulation has been well-studied, research on signaling after inflammasome triggers like nigericin is limited. We performed time-resolved phosphoproteomic profiling to explore kinase signaling downstream ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-27 | PXD062943 | Pride
Innate immunity Signalling pathways Phosphoproteomics Pyroptosis Inflammasomes 
ProteomicsNigericin-Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis
Innate immune signaling relies on phosphorylation cascades for effective responses. While TLR4 stimulation has been well-studied, research on signaling after inflammasome triggers like nigericin is limited. We performed time-resolved phosphoproteomic profiling to explore kinase signaling downstream ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-27 | PXD062818 | Pride
Innate immunity Signalling pathways Phosphoproteomics Pyroptosis Inflammasomes 
ProteomicsNigericin induced paraptosis-like cell death instead of pyroptosis in corneal keratocytes
Corneal wound healing involves complex cellular processes, including keratocyte cell death, which plays a pivotal role in initiating tissue repair. Recent studies suggest that pyroptosis, characterized by the release of pro-inflammatory factors, occurs during tissue repair which may also contribute ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD058468 | Pride
Proteomics Corneal keratocytes Nigericin 
UnknownApproach to nigericin derivatives and their therapeutic potential.
Not available
S-EPMC9058090 | biostudies-literature
UnknownNigericin-Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis.
Not available
S-EPMC12673643 | biostudies-literature
UnknownNigericin is effective against multidrug resistant gram-positive bacteria, persisters, and biofilms.
Not available
S-EPMC9807916 | biostudies-literature
UnknownMolecular Screening for Nigericin Treatment in Pancreatic Cancer by High-Throughput RNA Sequencing.
Not available
S-EPMC7411259 | biostudies-literature
UnknownNigericin Boosts Anti-Tumor Immune Response via Inducing Pyroptosis in Triple-Negative Breast Cancer.
Not available
S-EPMC10296105 | biostudies-literature
UnknownTargeting Multiple Homeostasis-Maintaining Systems by Ionophore Nigericin Is a Novel Approach for Senolysis.
Not available
S-EPMC9693507 | biostudies-literature
UnknownNigericin Induces Paraptosis-Like Cell Death Instead of Pyroptosis in Corneal Keratocytes.
Not available
S-EPMC12180573 | biostudies-literature
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