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ProteomicsTear proteins altered in patients with persistent eye pain after refractive surgery: biomarker candidate discovery
Some patients develop persistent eye pain after refractive surgery, but the factors that cause or sustain pain are unknown. We tested whether tear proteins of patients with pain 3 months after surgery differ from patients without pain. Patients undergoing refractive surgery (LASIK or PRK) were recru...
ORGANISM(S): Homo sapiens (Human) 
2025-05-25 | PXD051071 | Pride
Corneal pain Eye pain Mass spectrometry Prk Human tears Lasik Quantitative proteomics Biomarker Tandem mass tags 
TranscriptomicsCorneal Gene Expression Analysis
Transplantation of amniotic membrane-expanded limbal epithelium (AMLE) in place of donor tissue grafts results in significantly improved outcomes for patients suffering from severe limbal stem cell deficiency; however the reasons for such superior results are unclear. The purpose of this study was t...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-56421 | biostudies-arrayexpress
GenomicsGenome-Wide Binding of Ehf in mouse corneal epithelium
The cornea, composed of epithelium, stroma and endothelium, protects the anterior compartment of the eye from damage and allows transmission of light into the eye. While well described morphologically, no studies have investigated the global gene expression changes in the cornea throughout the mous...
ORGANISM(S): Mus musculus 
2013-08-27 | E-GEOD-44741 | biostudies-arrayexpress
TranscriptomicsHigh throughput gene expression analysis identifies reliable expression markers of human corneal endothelial cells.
Considerable interest has been generated for the development through cell-tissue engineering of suitable corneal endothelial graft alternatives, which can potentially alleviate the shortage of corneal transplant material. The advent of less invasive suture-less key-hole surgery options such as Desce...
ORGANISM(S): Homo sapiens 
2013-05-23 | E-GEOD-44064 | biostudies-arrayexpress
TranscriptomicsProinflammatory effect of Pseudomonas aeruginosa hook protein FlgE on human corneal epithelial cells
Recombinant protein of Pseudomonas aeruginosa hook protein FlgE was added to cultured human corneal epithelial cell line for 4 hours and the mRNA expression profiling was performed using Agilent 8*60K array and dual labeling. Three triplicates were included for FlgE treatment and PBS control respect...
ORGANISM(S): Homo sapiens 
2014-10-08 | E-GEOD-58422 | biostudies-arrayexpress
UnknownValidation of the Ocular Pain Assessment Survey Instrument With Rasch Analysis.
Not available
S-EPMC11838117 | biostudies-literature
UnknownCoexistence of neuropathic corneal pain, corneal nerve abnormalities, depression, and low quality of life.
Not available
S-EPMC10858266 | biostudies-literature
UnknownPain and sickness behavior associated with corneal lesions in dairy calves.
Not available
S-EPMC4758373 | biostudies-literature
UnknownEvidence for spinal disinhibition as a pain-generating mechanism in fibromyalgia syndrome.
Not available
S-EPMC11677609 | biostudies-literature
UnknownChronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent post-operative pain disorders.
Not available
S-EPMC4411662 | biostudies-literature
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