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ProteomicsRe-evaluation of the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: CIAPIN1 is a major target of VLX1570 for non-selective covalent modification and aggregation in a multiple myeloma model.
Deubiquitinating enzymes are a growing target class across multiple disease states, with several inhibitors now reported. b-AP15 and VLX1570 are two structurally related USP14/UCH-37 inhibitors. Initially taken forward into a phase I/II clinical trial for refractory Multiple Myeloma, VLX1570 has sin...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD015412 | Pride
Proteomics Vlx1570 Chemoproteomics Bap-15 Multiple myeloma 
UnknownRisk factors for COVID-19-related in-hospital mortality in a high HIV and tuberculosis prevalence setting in South Africa: a cohort study.

Background

The interaction between COVID-19, non-communicable diseases, and chronic infectious diseases such as HIV and tuberculosis is unclear, particularly in low-income and middle-income countries in Africa. South Africa has a national HIV prevalence of 19% among people aged 15-49 years a...
S-EPMC8336996 | biostudies-literature
UnknownDifference in mortality among individuals admitted to hospital with COVID-19 during the first and second waves in South Africa: a cohort study.

Background

The first wave of COVID-19 in South Africa peaked in July, 2020, and a larger second wave peaked in January, 2021, in which the SARS-CoV-2 501Y.V2 (Beta) lineage predominated. We aimed to compare in-hospital mortality and other patient characteristics between the first and second ...
S-EPMC8270522 | biostudies-literature
UnknownTrends in Mortality in People With HIV From 1999 through 2020: A Multicohort Collaboration.

Background

Mortality among people with human immunodeficiency virus (HIV) declined with the introduction of combination antiretroviral therapy. We investigated trends in mortality in people with HIV from 1999 through 2020.

Methods

Data were collected from the Data Collection on Advers...
S-EPMC11581700 | biostudies-literature
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