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TranscriptomicsIntegrative DNA, RNA and protein evidence connects TREML4 to coronary artery calcification
Peripheral blood RNA-Seq from human coronary artery calcification cases and controls; Coronary artery calcification (CAC) is a heritable and definitive morphologic marker of atherosclerosis that strongly predicts risk for future cardiovascular events. To search for genes involved in CAC, we used an ...
ORGANISM(S): Homo sapiens 
2014-06-10 | E-GEOD-58150 | biostudies-arrayexpress
TranscriptomicsmRNA expression profile in vascular smooth muscle cells (VSMCs) after inducing calcification
Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet to be elucidated. Here we report that MDM2-induced polyubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activi...
ORGANISM(S): Rattus norvegicus 
2015-11-07 | E-GEOD-74755 | biostudies-arrayexpress
ProteomicsEAT and coronary atherosclerosis in high-risk patients
Rationale: Epicardial adipose tissue (EAT) has been independently associated with non-calcified, high-risk coronary plaques in low-to intermediate risk subjects. Recently, a bidirectional communication was shown between EAT and diseased coronary arteries. In high-risk patients it is unknown whether ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-04 | PXD008852 | Pride
Coronary calcification Swath Epicardial adipose tissue Epicheart study 
ProteomicsHDL Proteomics in Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study
Atherosclerotic cardiovascular disease (CVD) is the major cause of death in patients with type 1 diabetes mellitus (T1DM). Alterations in the HDL proteome associate with prevalent CVD in T1DM. We therefore determined which proteins carried by HDL might predict incident CVD in T1DM patients. Using ta...
ORGANISM(S): Homo Sapiens 
2022-04-19 | PXD031854 | panorama
ProteomicsCarnitine O-octanoyltransferase is a novel inducer of vascular calcification via promoting fatty acid metabolism and mitochondrial dysfunction
Objective – Vascular calcification is a critical pathology associated with increased cardiovascular event risk, but there are no FDA-approved anti-calcific therapies. We hypothesized and validated that an unbiased screening approach would identify novel mediators of human vascular calcification. Ap...
ORGANISM(S): Homo sapiens (Human) 
2021-02-26 | PXD022575 | Pride
Human primary smooth muscle cells Crot Cardiovascular calcification 
ProteomicsScreening of Serum Biomarkers for Coronary Artery Calcification Using DIA Quantitative Proteomics and Construction of a Regression Model
Abstract Background: Using DIA quantitative proteomics technology to screen for coronary artery calcification (CAC)-associated differentially expressed proteins, this study explores the value of SMOC1, HSP90B1, and OPTN as potential serum biomarkers for CAC and constructs an individualized risk pre...
ORGANISM(S): Homo Sapiens 
2026-03-07 | PXD075378 |
TranscriptomicsIntegrative DNA, RNA and protein evidence connects TREML4 to coronary artery calcification
Peripheral blood RNA-Seq from human coronary artery calcification cases and controls; Coronary artery calcification (CAC) is a heritable and definitive morphologic marker of atherosclerosis that strongly predicts risk for future cardiovascular events. To search for genes involved in CAC, we used an ...
ORGANISM(S): Homo sapiens 
2014-06-10 | GSE58150 | GEO
GenomicsMicroRNA expression profiling for coronary artery calcification in Indian chronic kidney disease patients
Our study investigates the expression profilling of miRNAs in the pathogenesis of coronary artery calcification in chronic kidney disease patients and identify alter miRNA gene expression which will gives a unique platform for new drug discovery
ORGANISM(S): Homo sapiens 
2017-12-01 | GSE89699 | GEO
GenomicsCirculating miRNA profile and coronary calcification in asymptomatic patients with familial hypercholesterolemia.
Circulating miRNA profile and coronary calcification in asymptomatic patients with familial hypercholesterolemia.
PRJNA737428 | ENA
GenomicsNHLBI TOPMed: Diabetes Heart Study African American Coronary Artery Calcification (AA CAC)
NHLBI TOPMed: Diabetes Heart Study African American Coronary Artery Calcification (AA CAC)
PRJNA394787 | ENA
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