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ProteomicsCarnitine O-octanoyltransferase is a novel inducer of vascular calcification via promoting fatty acid metabolism and mitochondrial dysfunction
Objective – Vascular calcification is a critical pathology associated with increased cardiovascular event risk, but there are no FDA-approved anti-calcific therapies. We hypothesized and validated that an unbiased screening approach would identify novel mediators of human vascular calcification. Ap...
ORGANISM(S): Homo sapiens (Human) 
2021-02-26 | PXD022575 | Pride
Human primary smooth muscle cells Crot Cardiovascular calcification 
ProteomicsMitochondrial extracellular vesicles promote aortic valve calcification via carnitine O-octanoyltransferase
Calcific aortic valve disease (CAVD) is a leading cause of cardiovascular morbidity and mortality with no effective medical therapy. We previously identified carnitine O-octanoyltransferase (CROT) as a mediator of mitochondrial dysfunction and vascular calcification. However, its role in CAVD remain...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-05-13 | PXD072508 | Pride
Mitochondrial extracellular vesicles Aortic valve calcification Mitochondria Valvular interstitial cells Lc-ms/ms 
UnknownSingle Cell Gene Co-Expression Network Reveals FECH/CROT Signature as a Prognostic Marker.
Not available
S-EPMC6678878 | biostudies-literature
TranscriptomicsTranscriptome changes in mouse livers upon Bmal1 or Nr1d1 knock out and interactome of lnc-Crot by 4C-seq
To explore the circadian regulations of Bmal1, we examined the transcriptome changes in mouse livers upon Bmal1 knock out at two circadian time points, CT0 and CT12. To explore the circadian regulations of Nr1d1, we examined the transcriptome changes in mouse livers upon Nr1d1 knock out at two circa...
ORGANISM(S): Mus musculus 
2017-04-12 | GSE87299 | GEO
UnknownCROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.
Not available
S-EPMC8105275 | biostudies-literature
UnknownThe miR-33a-5p/CROT axis mediates ovarian cancer cell behaviors and chemoresistance via the regulation of the TGF-β signal pathway.
Not available
S-EPMC9478117 | biostudies-literature
ProteomicsCROT deficiency in mice leads to an increase of omega-3 fatty acids
Background Carnitine O-octanoyltransferase (CROT) is a well-established peroxisomal enzyme involved in liver fatty acid oxidation, but less is known about its recently discovered role in promoting vascular calcification, and whether CROT-dependent liver metabolism contributes to the latter. To date...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-05-14 | MSV000094756 | MassIVE
UnknownmiR‑126a‑5p‑Dbp and miR‑31a‑Crot/Mrpl4 interaction pairs crucial for the development of hypertension and stroke.
Not available
S-EPMC6797943 | biostudies-literature
ProteomicsCROT-mediated targeted metabolomics for nasopharyngeal carcinoma
Serum from 22 NPC patients and C666-1 cells with or without CROT knockdown were analyzed using targeted metabolomics to profile metabolic changes
ORGANISM(S): Homo Sapiens 
PXD069573 |
MetabolomicsGNPS - CROT deficiency in mice leads to an increase of omega-3 fatty acids
Background Carnitine O-octanoyltransferase (CROT) is a well-established peroxisomal enzyme involved in liver fatty acid oxidation, but less is known about its recently discovered role in promoting vascular calcification, and whether CROT-dependent liver metabolism contributes to the latter. To date...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-05-14 | MSV000094756 | GNPS
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