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ProteomicsEstrogen receptor beta isoforms interplay integrates nuclear and extra-nuclear signaling to modulate human granulosa cell growth
Estradiol (E2) is a central regulator of ovarian follicle development and granulosa cells (GCs) function, acting predominantly through estrogen receptor β (ERβ) in GCs. Human GCs co-express multiple ERβ isoforms (ERβ1, ERβ2, ERβ4 and ERβ5), yet how their relative abundance and crosstalk determine es...
ORGANISM(S): Homo sapiens (Human) 
2026-10-19 | PXD073667 | Pride
Signaling crosstalk Nuclear signaling Extra-nuclear signaling Estrogen receptor beta isoforms Cell growth Protein interactions Human granulosa cells Estradiol 
TranscriptomicsRNA-seq of human primary ovarian granulosa cells with knockdown of ESR2 isoform 1, treated with estradiol
ERβ1 is the predominant isoform mediating transcriptional activity in granulosa cells; however, ERβ1-specific target genes remain largely unknown. Here, we performed transcriptomic analysis of primary human granulosa cells with specific knockdown of ERβ1 and stimulation with estradiol (E2), an ERβ a...
ORGANISM(S): Homo sapiens 
2026-06-30 | E-MTAB-16651 | biostudies-arrayexpress
UnknownEffect of dexamethasone on complications or all cause mortality after major non-cardiac surgery: multicentre, double blind, randomised controlled trial.
Not available
S-EPMC8171383 | biostudies-literature
UnknownCOVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with rituximab: a cohort study.
Not available
S-EPMC7993930 | biostudies-literature
UnknownCOVID-19 infection among patients with autoinflammatory diseases: a study on 117 French patients compared with 1545 from the French RMD COVID-19 cohort: COVIMAI - the French cohort study of SARS-CoV-2 infection in patient with systemic autoinflammatory diseases.
Not available
S-EPMC9091487 | biostudies-literature
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