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ProteomicsPosition-specific N- and O-glycosylation of the reactive centre loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin
Corticosteroid-binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues through the proteolytic cleavage of an exposed reactive centre loop (RCL) by neutrophil elastase (NE). We previously demonstrated that RCL-localised Asn347-linked N-glycans impact NE proteolysis, but a comp...
ORGANISM(S): Homo sapiens (Human) 
2023-12-05 | PXD046405 | Pride
Glycosylation O-glycosylation Corticosteroid-binding globulin Cortisol N-glycosylation Proteolysis Reactive centre loop Neutrophil elastase 
GenomicsCorticosteroid-binding globulin (SERPINA6) consolidates sexual dimorphism of adult rat liver
Corticosteroid-binding globulin (SERPINA6) consolidates sexual dimorphism of adult rat liver
PRJNA1027865 | ENA
TranscriptomicsCorticosteroid-binding globulin (SERPINA6) consolidates sexual dimorphism of adult rat liver
Produced by the liver, corticosteroid-binding globulin (CBG) regulates the plasma distribution and actions of glucocorticoids. A sex difference in pituitary growth hormone secretion patterns established during puberty in rats results in increased hepatic CBG production and two-fold higher plasma cor...
ORGANISM(S): Rattus norvegicus 
2023-11-03 | GSE245348 | GEO
UnknownFunctional implications of corticosteroid-binding globulin N-glycosylation.
Not available
S-EPMC5793714 | biostudies-literature
UnknownN-Glycosylation influences human corticosteroid-binding globulin measurements.
Not available
S-EPMC6686952 | biostudies-literature
UnknownAvian corticosteroid-binding globulin: biological function and regulatory mechanisms in physiological stress responses.
Not available
S-EPMC8086359 | biostudies-literature
UnknownCorticosteroid-binding globulin: structure-function implications from species differences.
Not available
S-EPMC3530532 | biostudies-literature
ProteomicsRCL glycosylation of serum corticosteroid-binding globulin: implications in cortisol delivery and septic shock
Corticosteroid-binding globulin (CBG) is a serum glycoprotein that binds and delivers anti-inflammatory cortisol to inflammatory sites through neutrophil elastase (NE)-mediated proteolysis of an exposed reactive centre loop (RCL) on CBG. Timely and tissue-specific delivery of cortisol is critical to...
ORGANISM(S): Homo sapiens (Human) 
2025-03-07 | PXD058963 | Pride
Human serum Septic shock O-glycosylation Lc-ms/ms 
UnknownNeutrophil elastase-cleaved corticosteroid-binding globulin is absent in human plasma.
Not available
S-EPMC6347282 | biostudies-literature
UnknownN-glycans modulate the function of human corticosteroid-binding globulin.
Not available
S-EPMC3149095 | biostudies-literature
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