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MetabolomicsA Metabolomic Approach for Predicting Diurnal Changes in Cortisol

INTRODUCTION: The dysregulation of cortisol secretion has been associated with a number of mental health and mood disorders. However, diagnostics for mental health and mood disorders are behavioral and lack biological contexts.

OBJECTIVES: The goal of this ...

2021-09-23 | MTBLS1206 | MetaboLights
MetabolomicsDifferent Metabolic Pathways Associated With Total Cortisol Exposure and the Cortisol Time Profile: A Randomized Crossover Trial

Excess cortisol exposure and disruption of the circadian cortisol profile are both associated with adverse clinical outcomes. The aim of this study was to identify unique metabolites and metabolic pathways associated with total cortisol exposure and/or variation of the cortisol time profile. Eigh...

2026-01-16 | MTBLS13147 | MetaboLights
TranscriptomicsEffect of 10 or 25 days cortisol treatment on late gestation fetal septum
We have previously shown in sheep that 10 days of modest chronic increase in maternal cortisol result in fetal heart enlargement and Purkinje cell apoptosis. In subsequent studies in which we extended the duration of cortisol infusion (1mg/kg/d) to term, we found a dramatic incidence of stillbirth i...
ORGANISM(S): Ovis aries 
2014-08-07 | E-GEOD-54237 | biostudies-arrayexpress
MetabolomicsLipidomics of Newborn Heart Tissue Exposed to Excess Maternal Cortisol in Late Gestation (part-1)
Not available
ORGANISM(S): Ovis aries 
ST001106 | MetabolomicsWorkbench
MetabolomicsNMR Metabolomics of Newborn Heart Tissue Exposed to Excess Maternal Cortisol in Late Gestation (part -II)
Not available
ORGANISM(S): Ovis aries 
ST001107 | MetabolomicsWorkbench
MetabolomicsNMR Metabolomics of Newborn Heart Tissue Exposed to Excess Maternal Cortisol in Late Gestation - Maternal (part -IV)
Not available
ORGANISM(S): Ovis aries 
ST001109 | MetabolomicsWorkbench
MetabolomicsNMR Metabolomics of Newborn Heart Tissue Exposed to Excess Maternal Cortisol in Late Gestation - Fetal (part -III)
Not available
ORGANISM(S): Ovis aries 
ST001108 | MetabolomicsWorkbench
MetabolomicsPharmacokinetic and urinary profiling reveals prednisolone/cortisol ratio as a valid biomarker for prednisolone administration
In Europe, synthetic corticosteroids are not allowed in animal breeding fro growth-promoting purposes. Nevertheless, a high prevalence of non-compliant urine samples was recently reported for prednisolone, however, without any indication of unauthorized use. Within this context, 20b-dihydroprednisol...
2018-01-23 | MTBLS488 | MetaboLights
TranscriptomicsTranscription profiling of human HeLa cells treated by various doses of cortisol
Glucocorticoids act through the glucocorticoid receptor (GR), a ligand activated transcription factor, to modulate gene expression profiles in target cells and tissues. The principal physiological glucocorticoid in humans, cortisol, is released in a pulsatile fashion from the adrenal gland, which r...
ORGANISM(S): Homo sapiens 
2010-07-10 | E-MEXP-2447 | biostudies-arrayexpress
ProteomicsCortisol binding sites on SARS-CoV-2 S1 identified by limited proteolysis-coupled mass spectrometry
We used a limited proteolysis-coupled mass spectrometry approach to pinpoint binding sites of cortisol on SARS-CoV-2 S1. Binding target identification is based on the principle that small-ligand binding alters (increases or decreases) the protease accessibility of the target protein37,38. The bindin...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-06-10 | PXD032937 | Pride
Limited proteolysis Lc-ms Cortisol Covid-19 Sars-cov2 spike s1 
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