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TranscriptomicsE2F1 loss induces spontaneous tumour development in Rb-deficient epidermis
The specific ablation of Rb1 gene in epidermis (RbF/F;K14cre) promotes proliferation and altered differentiation but does not produce spontaneous tumour development. These phenotypic changes are associated with increased expression of E2F members and E2F-dependent transcriptional activity. Here, we ...
ORGANISM(S): Mus musculus 
2012-08-20 | E-GEOD-38048 | biostudies-arrayexpress
TranscriptomicsA Novel Tumor suppressor network in squamous malignancies
The specific ablation of Rb1 gene in stratified epithelia (RbF/F;K14cre) promotes proliferation and altered differentiation but is insufficient to produce spontaneous tumors. The pRb relative, p107, compensates some of the functions of pRb in these tissues, however RbF/F;K14cre;p107-/- mice die post...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-38257 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy (testing dataset)
The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the simultaneous ablation of Rb gene. Since alterations of p53-dependent pathway are common hallmarks of aggressive, poor prognostic human cancers,...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-19616 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy (training dataset)
The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the simultaneous ablation of Rb gene. Since alterations of p53-dependent pathway are common hallmarks of aggressive, poor prognostic human cancers,...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-11990 | biostudies-arrayexpress
TranscriptomicsIn vivo disruption of Rb-E2F-Ezh2 signaling loop causes bladder cancer development
Bladder cancer (BC) is a highly prevalent human disease in which Rb pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here we show that the in vivo inactivation of all Rb family genes in the mouse urothe...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-38264 | biostudies-arrayexpress
TranscriptomicsVav proteins orchestrate a keratinocyte auto/paracrine program critical for skin tumorigenesis.
Cutaneous squamous tumors rely on autocrine/paracrine loops for proper fitness. Targeting this Achilles’ heel is therefore considered a potential avenue for patient treatment. However, the mechanisms that engage and sustain such programs during tumor ontogeny are poorly understood. Here, we show ...
ORGANISM(S): Mus musculus 
2013-07-30 | E-GEOD-40849 | biostudies-arrayexpress
UnknownUsefulness of Routine Fractional Flow Reserve for Clinical Management of Coronary Artery Disease in Patients With Diabetes.
Not available
S-EPMC6990935 | biostudies-literature
TranscriptomicsA Functional Role of RB-Dependent Pathway in the Control of Quiescence in Adult Epidermal Stem Cells Revealed by Genomic Profiling
Continuous cell renewal in mouse epidermis is at the expense of a pool of pluripotent cells that lie in a well defined niche in the hair follicle known as the bulge. To identify mechanisms controlling hair follicle stem cell homeostasis, we developed a strategy to isolate adult bulge stem cells in m...
ORGANISM(S): Mus musculus 
2010-03-20 | E-GEOD-19448 | biostudies-arrayexpress
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