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ProteomicsMolecular architecture of photoreceptor phosphodiesterase (PDE6) with activated G protein elucidates the mechanism of visual excitation
Photoreceptor phosphodiesterase 6 (PDE6) is the central effector of the visual excitation pathway in both rod and cone photoreceptors, and PDE6 mutations that alter PDE6 structure or regulation can result in several human retinal diseases. The rod PDE6 holoenzyme consists of two catalytic subunits (...
ORGANISM(S): Bos taurus (Bovine) 
2019-11-11 | PXD015989 | Pride
Pde6 Chemical cross-linking 
ProteomicsStructural analysis of the regulatory GAF domains of cGMP phosphodiesterase elucidates the allosteric communication pathway
Regulation of photoreceptor phosphodiesterase (PDE6) activity is responsible for the speed, sensitivity, and recovery of the photoresponse during visual signaling in vertebrate photoreceptor cells. It is hypothesized that the physiological differences in the light responsiveness of rods and cones ma...
ORGANISM(S): Gallus gallus (Chicken) 
2022-02-15 | PXD020817 | Pride
Pde6 Allosteric regulation Chemical cross-linking Mass spectrometry Structural biology X-ray crystallography Nuclear magnetic resonance spectroscopy Integrative structural modeling 
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