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ProteomicsMolecular architecture of photoreceptor phosphodiesterase (PDE6) with activated G protein elucidates the mechanism of visual excitation
Photoreceptor phosphodiesterase 6 (PDE6) is the central effector of the visual excitation pathway in both rod and cone photoreceptors, and PDE6 mutations that alter PDE6 structure or regulation can result in several human retinal diseases. The rod PDE6 holoenzyme consists of two catalytic subunits (...
ORGANISM(S): Bos taurus (Bovine) 
2019-11-11 | PXD015989 | Pride
Pde6 Chemical cross-linking 
UnknownRod phosphodiesterase-6 (PDE6) catalytic subunits restore cone function in a mouse model lacking cone PDE6 catalytic subunit.
Not available
S-EPMC3190866 | biostudies-literature
ProteomicsFunctional Asymmetry and Essential Structural Roles of PDE6α and PDE6β Subunits in Rod Photoreceptor Integrity
Tetrameric rod phosphodiesterase 6 (PDE6) critically regulates cyclic GMP (cGMP) levels in rod photoreceptors comprised of catalytic core α/β heterodimer and two small inhibitory γ subunits. While the rod PDE6 catalytic core is a heterodimer, the cone isoform is an α'/α' homodimer. This structural d...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-25 | PXD073183 | Pride
Cgmp Phosphodiesterase 6 Outer segment Rod photoreceptor Visual transduction 
ProteomicsStructural analysis of the regulatory GAF domains of cGMP phosphodiesterase elucidates the allosteric communication pathway
Regulation of photoreceptor phosphodiesterase (PDE6) activity is responsible for the speed, sensitivity, and recovery of the photoresponse during visual signaling in vertebrate photoreceptor cells. It is hypothesized that the physiological differences in the light responsiveness of rods and cones ma...
ORGANISM(S): Gallus gallus (Chicken) 
2022-02-15 | PXD020817 | Pride
Pde6 Allosteric regulation Chemical cross-linking Mass spectrometry Structural biology X-ray crystallography Nuclear magnetic resonance spectroscopy Integrative structural modeling 
UnknownThe N termini of the inhibitory γ-subunits of phosphodiesterase-6 (PDE6) from rod and cone photoreceptors differentially regulate transducin-mediated PDE6 activation.
Not available
S-EPMC6544851 | biostudies-literature
UnknownMechanisms of mutant PDE6 proteins underlying retinal diseases.
Not available
S-EPMC5554458 | biostudies-literature
UnknownDomain organization and conformational plasticity of the G protein effector, PDE6.
Not available
S-EPMC4432299 | biostudies-literature
UnknownCone Phosphodiesterase-6γ' Subunit Augments Cone PDE6 Holoenzyme Assembly and Stability in a Mouse Model Lacking Both Rod and Cone PDE6 Catalytic Subunits.
Not available
S-EPMC6046437 | biostudies-literature
UnknownPhotoreceptor Phosphodiesterase (PDE6): Structure, Regulatory Mechanisms, and Implications for Treatment of Retinal Diseases.
Not available
S-EPMC9434729 | biostudies-literature
UnknownPhotoreceptor phosphodiesterase (PDE6): activation and inactivation mechanisms during visual transduction in rods and cones.
Not available
S-EPMC8376765 | biostudies-literature
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