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TranscriptomicsCotranslational signal independent SRP preloading during membrane targeting
Cotranslational targeting into the endoplasmic reticulum (ER) by the Signal Recognition Particle (SRP) is a key event determining polypeptide fate in eukaryotic cells. Here, we globally define the principles and mechanisms of SRP binding and ER targeting in vivo. Cotranslational targeting through SR...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-03 | E-GEOD-74393 | biostudies-arrayexpress
Genomicscotranslational assembly and chaperone binding
Molecular drivers of cotranslational protein assembly in bacteria
PRJEB108825 | ENA
GenomicsRibosome profiling reveals multiple roles of SecA in cotranslational protein export
Ribosome profiling reveals multiple roles of SecA in cotranslational protein export
PRJNA769692 | ENA
GenomicsPrinciples of cotranslational mitochondrial protein import revealed by selective ribosome profiling
Principles of cotranslational mitochondrial protein import revealed by selective ribosome profiling
PRJNA1076084 | ENA
GenomicsCotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling
Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling
PRJNA479682 | ENA
TranscriptomicsSelective ribosome profiling reveals the co-translational chaperone action of trigger factor in vivo
As nascent polypeptides exit ribosomes, they are engaged by a series of processing, targeting and folding factors. Here we present a selective ribosome profiling strategy that enables global monitoring of when these factors engage polypeptides in the complex cellular environment. Studies of the Esch...
ORGANISM(S): Escherichia coli 
2011-12-09 | E-GEOD-33671 | biostudies-arrayexpress
TranscriptomicsRibosome profiling reveals multiple roles of SecA in cotranslational protein export
SecA, an ATPase known to posttranslationally translocate secretory proteins across the bacterial plasma membrane, also interacts with ribosomes. Here, we used a combination of ribosome profiling methods to investigate the cotranslational actions of SecA in vivo. SecA scans translating ribosomes at t...
ORGANISM(S): Escherichia coli 
2022-05-16 | GSE185572 | GEO
TranscriptomicsCotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling
Folding of newly synthesized proteins to the native state is a major challenge within the crowded cellular environment, since non-productive interactions can lead to misfolding, aggregation and degradation1. Cells cope with this challenge by coupling synthesis with polypeptide folding and by employi...
ORGANISM(S): Saccharomyces cerevisiae BY4741 
2018-07-05 | GSE116570 | GEO
OtherPromoter architecture determines cotranslational regulation of mRNA
Information that regulates gene expression is encoded throughout each gene but if different regulatory regions can be understood in isolation, or if they interact, is unknown. Here we measure mRNA levels for 10,000 open reading frames (ORFs) transcribed from either an inducible or constitutive promo...
ORGANISM(S): Saccharomyces cerevisiae 
2017-06-28 | GSE100452 | GEO
GenomicsThe Hsp90 cochaperone TTT promotes cotranslational maturation of PIKK kinases prior to complex assembly
The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKK kinases prior to complex assembly
PRJNA761401 | ENA
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