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ProteomicsThioamide-warheads with enhanced cysteine reactivity and specificity for targeted covalent inhibitors
Targeted covalent inhibitors (TCIs) form covalent bond with their target that requires tailored reactive functionalities identified as warheads. Here we present a versatile approach changing carboxamide functions with thioamides that transforms known warheads to softer electrophiles enhancing reacti...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD054470 | Pride
Warhead Proteomics Cystein Covalent inhibitors 
UnknowntagPAINT: covalent labelling of genetically encoded protein tags for DNA-PAINT imaging.
Not available
S-EPMC6936279 | biostudies-literature
ProteomicsCovalent labelling of UNC119 with alkyl bromide compound 7
UNC119 protein was treated with compound 7 (10:1 in excess, overnight) to see if covalent modification can be achieved with this alkyl bromide derivative at E163. Untreated UNC119 was used as negative control in comparison.
ORGANISM(S): Homo sapiens (Human) 
2026-01-08 | PXD067823 | Pride
Targeted covalent inhibitors Unc119 Glu-targeted inhibition Alkyl bromide reactivity 
UnknownExploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues.
Not available
S-EPMC11960843 | biostudies-literature
UnknownLigand-directed covalent labelling of a GPCR with a fluorescent tag in live cells.
Not available
S-EPMC7695831 | biostudies-literature
UnknownTet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing.
Not available
S-EPMC3679896 | biostudies-literature
UnknownMicrogel PAINT - nanoscopic polarity imaging of adaptive microgels without covalent labelling.
Not available
S-EPMC6984396 | biostudies-literature
UnknownOrthogonal coiled coils enable rapid covalent labelling of two distinct membrane proteins with peptide nucleic acid barcodes.
Not available
S-EPMC8341593 | biostudies-literature
TranscriptomicsDNA unmethylome profiling by covalent capture of CpG sites (microarray)
Here we present an approach for the mapping of unmethylated DNA. Our technique is based on DNA methyltransferase-directed transfer of activated groups (mTAG) and covalent biotin tagging of unmodified CpG sites followed by affinity enrichment and interogation on tiling microarrays or next generation ...
ORGANISM(S): Homo sapiens 
2013-08-27 | E-GEOD-49044 | biostudies-arrayexpress
ProteomicsAlternate covalent form of platelet αIIbβ3
The αIIbβ3 integrin receptor coordinates platelet adhesion, activation and mechanosensing in thrombosis and haemostasis. Using differential cysteine alkylation and mass spectrometry, we have identified a disulfide bond in the αIIb subunit linking cysteines 490 and 545 that is missing in about one in...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025907 | Pride
Αiibβ3 Platelet Disulfide Covalent Integrin 
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