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ProteomicsExpanding the repertoire of chemically induced covalent neoantigens
The ubiquitin-proteasome system (UPS) generates peptide fragments that are displayed on class I major histocompatibility complex (MHC-I) molecules. Hapten-modified peptides, which are derived from proteins covalently modified by exogenous small molecules, have long been proposed as a mechanism for i...
ORGANISM(S): Homo sapiens (Human) 
2026-07-08 | PXD077352 | Pride
Immunopeptidomics Covalent neoantigens Mhc-i 
UnknownCreating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy.
Not available
S-EPMC9827112 | biostudies-literature
UnknownGeneration of actionable, cancer-specific neoantigens from KRAS(G12C) with adagrasib.
Not available
S-EPMC12337345 | biostudies-literature
UnknownEngineered antibodies that stabilize drug-modified KRAS<sup>G12C</sup> neoantigens enable selective and potent cross-HLA immunotherapy.
Not available
S-EPMC12717047 | biostudies-literature
ProteomicsEngineered antibodies that stabilize drug-modified KRASG12C neoantigens enable selective and potent cross-HLA immunotherapy
Covalent inhibitors of the oncoprotein KRAS have significant initial efficacy, but responses lack durability. Covalent inhibitor-modified oncoproteins are presented as MHC-restricted hapten-peptides (p*MHC) on the cancer cell surface, creating an opportunity to combine targeted therapy with immunoth...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-21 | MSV000097193 | MassIVE
UnknownA covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy.
Not available
S-EPMC10393267 | biostudies-literature
ProteomicsA platform for mapping reactive cysteines within the immunopeptidome
The major histocompatibility complex class I (MHC-I) antigen presentation pathways play pivotal roles in orchestrating immune responses. Recent studies have begun to utilize cysteines within the immunopeptidome for therapeutic applications, such as using covalent ligands to create haptenated neoanti...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD054678 | Pride
Immunopeptidome Reactive cysteines 
UnknownDirect evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients.
Not available
S-EPMC3164351 | biostudies-literature
UnknownIdentification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury.
Not available
S-EPMC10371196 | biostudies-literature
UnknownGeneration of triacyl lipopeptide-modified glycoproteins by metabolic glycoengineering as the neoantigen to boost anti-tumor immune response.
Not available
S-EPMC8210591 | biostudies-literature
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