Sort   by:  
 Page size 
MetabolomicsFatal COVID-19 pulmonary disease involves ferroptosis.

SARS-CoV-2 infection causes severe pulmonary manifestations, with poorly understood mechanisms and limited treatment options. Hyperferritinemia and disrupted lung iron homeostasis in COVID-19 patients imply that ferroptosis, an iron-dependent cell death, may occur. Immunostaining and lipidomic an...

2024-07-11 | MTBLS3107 | MetaboLights
MetabolomicsMetabolomics Analysis Identifies Glutamic acid and Cystine imbalances in COVID-19 Patients Without Comorbid Conditions. Implications on Redox Homeostasis and COVID-19 Pathophysiology

It is well known that the presence of comorbidities and age-related health issues may hide biochemical and metabolic features triggered by SARS-CoV-2 infection and other diseases associated to hypoxia, as they are by themselves chronic inflammatory conditions that may potentially disturb metaboli...

2024-08-26 | MTBLS5011 | MetaboLights
MetabolomicsA Multi-omics Longitudinal Study Reveals Alteration of the Leukocyte Activation Pathway in COVID-19 Patients
Severe coronavirus disease 2019 (COVID-19) infection may lead to lung injury, multi-organ failure, and eventually death. Cytokine storm due to excess cytokine production has been associated with fatality in severe infections. However, the specific molecular signatures associated with the elevated im...
2022-01-18 | MTBLS2469 | MetaboLights
MetabolomicsKynurenic acid underlies sex-specific immune responses to COVID-19
Sex-related differences in Coronavirus Disease (COVID-19) severity and mortality exist, with the male sex being a potential risk factor1. It was recently shown that patients with mild to moderate SARS-CoV-2 infection have elevated levels of inflammatory cytokines and chemokines, and sex-differences ...
2020-09-08 | MTBLS1987 | MetaboLights
MetabolomicsDysregulation of lipid metabolism and pathological inflammation in patients with COVID-19
In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring access to specialized intensive care. SARS-CoV-2 infec...
2023-02-01 | MTBLS6844 | MetaboLights
MetabolomicsQuantitative LC-MS study of compounds found predictive of COVID-19 severity and outcome

INTRODUCTION: Since the beginning of the SARS-CoV-2 pandemic in December 2019 multiple metabolomics studies have proposed predictive biomarkers of infection severity and outcome. Whilst some trends have emerged, the findings remain intangible and uninformative when it comes to n...

2024-04-23 | MTBLS7429 | MetaboLights
MetabolomicsProphylactic and therapeutic itaconate treatment alleviates COVID-19-associated lung injury

Although itaconate demonstrates anti-inflammatory and antimicrobial properties as an immunomodulatory metabolite, the therapeutic potential and mechanistic basis of vaccine-induced or prophylactic itaconate administration in COVID-19 intervention remains underexplored. Our studies reveal that int...

2025-08-06 | MTBLS12827 | MetaboLights
TranscriptomicsDeciphering the molecular immune response to COVID-19 using single cell multi-omics
Multi-omics single-cell profiling of surface proteins, gene expression and lymphocyte immune receptors from hospitalised COVID-19 patient peripheral blood immune cells and healthy controls donors. Identification of the coordinated immune cell compositional and state changes in response to SARS-CoV-2...
ORGANISM(S): Homo sapiens 
2021-03-17 | E-MTAB-10026 | biostudies-arrayexpress
ProteomicsDiscovery and systematic assessment of early biomarkers that predict progression to severe COVID-19 disease - 2nd cohort
In order to identify differentially abundant proteins, human plasma samples from COVID-19 patients with either a mild or moderate (MM) or a critical or severe (CS) disease course from acute phase of infection were analyzed on antibody microarrays 998 different proteins by 1,425 antibodies.
ORGANISM(S): Homo sapiens 
2023-03-15 | E-MTAB-12777 | biostudies-arrayexpress
ProteomicsDiscovery and systematic assessment of early biomarkers that predict progression to severe COVID-19 disease - 1st cohort
In order to identify differentially abundant proteins, human plasma samples from COVID-19 patients with either a mild or moderate (MM) or a critical or severe (CS) disease course from the acute phases of infection were analyzed on antibody microarrays targeting 351 different proteins by 517 antibodi...
ORGANISM(S): Homo sapiens 
2023-04-11 | E-MTAB-12779 | biostudies-arrayexpress
Sort   by:  
 Page size