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TranscriptomicsTranscription profiling by array of human adipose tissue from hypopituitary men before and after growth hormon (GH) treatment.
Adipose tissue is a major target of GH action. GH stimulates lipolysis and reduces fat mass. The molecular mechanism underlying cellular and metabolic effects of GH in adipose tissue is not well understood. The aim of this study is to identify GH-responsive genes that regulate lipid metabolism in ad...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MTAB-276 | biostudies-arrayexpress
TranscriptomicsWhite Matter transcriptome in chronic alcoholism
Chronic alcohol consumption can lead to alchohol-related brain damage (ARBD). Despite the well known acute effects of alcohol the mechanism responsible for chronic brain damage is largely unknown. Pathologically the major change is the loss of white matter while neuronal loss is mild and restricted ...
ORGANISM(S): Homo sapiens 
2014-01-04 | E-GEOD-53808 | biostudies-arrayexpress
ProteomicsProximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation
Lysine specific demethylase 1 (LSD1/KDM1A) regulates gene expression as part of the CoREST complex, along with co-repressor of REST (CoREST) and histone deacetylase 1 (HDAC1). CoREST is recruited to specific genomic loci by components of the core complex and numerous transient interactions with chro...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-11-03 | PXD017344 | Pride
Embryonic stem cell Differentiation Bioid 
ProteomicsThe six unique histone deacetylase (HDAC) 1 complexes vary greatly in abundance and utilize distinct molecular assemblies.
Histone deacetylase 1 and 2 (HDAC1/2) are highly related enzymes that that regulate histone acetylation levels in all cells, as catalytic and structural components of six unique multi-protein complexes: SIN3, NuRD, CoREST, MIDAC, MIER1 and RERE. Co-immunoprecipitation of HDAC1-Flag followed by mass-...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-22 | PXD060158 | Pride
Acetylation Hdac1 Protein complex Chromatin modification 
ProteomicsThe six unique histone deacetylase (HDAC) 1 complexes vary greatly in abundance and utilize distinct molecular assemblies.
Histone deacetylase 1 and 2 (HDAC1/2) are highly related enzymes that that regulate histone acetylation levels in all cells, as catalytic and structural components of six unique multi-protein complexes: SIN3, NuRD, CoREST, MIDAC, MIER1 and RERE. Co-immunoprecipitation of HDAC1-Flag followed by mass-...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-22 | PXD060154 | Pride
Acetylation Hdac1 Protein complex Chromation modification 
TranscriptomicsAn early inflammatory gene profile in visceral adipose tissue in children
The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n=71, [54 boys], 6.0 +- 4.3 years). Affymetrix microarrays (n=20) were performed to characterize the fun...
ORGANISM(S): Homo sapiens 
2011-06-04 | E-GEOD-29718 | biostudies-arrayexpress
TranscriptomicsThe ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-12-27 | E-GEOD-30407 | biostudies-arrayexpress
TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
UnknownClinical interpretation of KCNH2 variants using a robust PS3/BS3 functional patch-clamp assay.
Not available
S-EPMC10840334 | biostudies-literature
UnknownTranscription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing.
Not available
S-EPMC7470969 | biostudies-literature
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