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TranscriptomicsGenetic disruption of COX-1 inhibits multiple oncogenic pathways
We performed RNA sequencing in isogenic models of COX-1 proficient (OV3/SCR) and COX-1 deficient (OV3/COX1KD) OVCAR-3 ovarian cancer cells. COX-1 knockdown was associated with a coordinated anti-oncogenic phenotype, with growth, angiogenesis, migration/invasion, and epithelial-mesenchymal transition...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-66173 | biostudies-arrayexpress
TranscriptomicsFeedback amplication of fibrosis through matrix stiffening and COX-2 suppression
We tested the hypothesis that increasing matrix stiffness on which normal human lung fibroblasts are grown promotes the expression of a fibrogenic cellular transcriptomic program. Keywords: Human lung fibroblast, matrix stiffness, PTGS2, COX-2, Prostaglandin E2 Total RNA extracted from normal human...
ORGANISM(S): Homo sapiens 
2010-07-15 | E-GEOD-22011 | biostudies-arrayexpress
UnknownDiscovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer.
Not available
S-EPMC6545551 | biostudies-literature
UnknownAberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer.
Not available
S-EPMC4673270 | biostudies-literature
UnknownBayesian Adaptive Randomization Trial of Passive Scattering Proton Therapy and Intensity-Modulated Photon Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer.
Not available
S-EPMC6008104 | biostudies-literature
TranscriptomicsNF-κB target gene microarray in HAECs in response to Pseudomonas aeruginosa
An NF-κB target gene array (Panomics, Inc., Redwood City, CA) was performed to profile the PAO1-dependent expression pattern of 111 NF-kB-regulated genes in primary human airway epithelial cells (HAECs). A small scale microarray was carried out using NF-κB target gene array kit (Panomics, Inc., Redw...
ORGANISM(S): Homo sapiens 
2007-09-08 | E-GEOD-8986 | biostudies-arrayexpress
TranscriptomicsDerivation and Evaluation of Putative Adverse Outcome Pathways for the Effects of Cyclooxygenase Inhibitors on Reproductive Processes in Fish
Cyclooxygenase (COX) inhibition is of concern in fish because COX inhibitors (e.g., ibuprofen) are ubiquitous in aquatic systems/fish tissues, and can disrupt synthesis of prostaglandins that modulate a variety of essential biological functions including reproduction. Transcriptomic data and publicl...
ORGANISM(S): Pimephales promelas 
2016-01-14 | E-GEOD-72976 | biostudies-arrayexpress
TranscriptomicsLong non-coding RNAs act as novel mediators of Innate Immunity
Recent advances in genome technologies have uncovered thousands of long non-coding RNAs (lncRNAs) whose function in the immune system has been largely unexplored. Members of the Toll-like receptor (TLR) family activate an inducible program of inflammatory genes important in host defenses. Here we p...
ORGANISM(S): Mus musculus 
2013-08-26 | E-GEOD-40978 | biostudies-arrayexpress
TranscriptomicsSynthetic lethal screening with small molecule inhibitors provides a pathway to rational combination therapies for melanoma
Recent data demonstrate that extracellular signals are transmitted through a network of proteins rather than hierarchical signaling pathways. This network model suggests why inhibition of a single component of a canonical pathway, even when targeting a mutationally activated driver of cancer, has in...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-39192 | biostudies-arrayexpress
UnknownAPOL1 Genotype, Proteinuria, and the Risk of Kidney Failure: A Secondary Analysis of the AASK (African American Study of Kidney Disease and Hypertension) and CRIC (Chronic Renal Insufficiency Cohort) Studies.
Not available
S-EPMC9720339 | biostudies-literature
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