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ProteomicsStructuring lipid nanoparticles, DNA, and protein corona into stealth bionanoarchitectures for in vivo gene delivery
Lipid nanoparticles (LNPs) play a crucial role in addressing genetic disorders, and cancer, and combating pandemics such as COVID-19 and its variants. Yet, in contrast remarkable achievements in siRNA and mRNA delivery, the ability of LNPs to effectively encapsulate large-size DNA molecules remains ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-02 | PXD054751 | Pride
Protein corona Lipid nanoparticles Dna 
UnknownHow do integrated health care systems address racial and ethnic disparities in colon cancer?
Not available
S-EPMC4348634 | biostudies-literature
TranscriptomicsExpression of the placental transcriptome in fetal growth restriction in the Baboon is Dependent on Fetal Sex
Fetal growth restriction (FGR) develops when fetal nutrient availability is compromised and increases the risk for perinatal complications and predisposes for offspring obesity, diabetes and cardiovascular disease later in life. Emerging evidence implicates changes in placental function in altered f...
ORGANISM(S): Papio hamadryas 
2013-12-06 | E-GEOD-40878 | biostudies-arrayexpress
GenomicsA Comprehensive Catalogue of Somatic Mutations from a Human Cancer Genome
We have carried out complete sequencing of the genome of the human male maligant melanoma cell line COLO-829 using the Illumina Genome Analyzer II. We generated a sequencing library with a median insert size of ~200 bp following random fragmentation and gel fractionation of the genomic DNA. We seque...
EGAS00000000052 | EGA
UnknownDepth of Response in Multiple Myeloma: A Pooled Analysis of Three PETHEMA/GEM Clinical Trials.
Not available
S-EPMC5568033 | biostudies-literature
TranscriptomicsMicroarray hybridization data from the root tips of 5-day-old Arabidopsis thaliana seedlings grown on tilted, hard agar surfaces
The growth behavior of plant roots on tilted, hard agar surfaces is determined by many basic cellular processes, including microtubule dynamics and cell wall expansion. Among Arabidopsis thaliana accessions there is natural variation for these behaviors, including one known as skewing or slanting. ...
ORGANISM(S): Arabidopsis thaliana 
2011-03-31 | E-GEOD-28275 | biostudies-arrayexpress
TranscriptomicsErbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation.
Exposure to ultraviolet (UV) irradiation is the major cause of nonmelanoma skin cancer, the most common form of cancer in the United States. UV irradiation has a variety of effects on the skin associated with carcinogenesis, including DNA damage and effects on signal transduction. The alterations in...
ORGANISM(S): Mus musculus 
2006-07-01 | E-GEOD-4066 | biostudies-arrayexpress
UnknownRole of the repeat expansion size in predicting age of onset and severity in RFC1 disease.
Not available
S-EPMC11068103 | biostudies-literature
GenomicsEGAD00000000055
COLO-829 is a publicly available immortal cancer cell line and COLO-829BL is a lymphoblastoid cell line derived from the same patient
EGAD00000000055 | EGA
Genomicsena-DATASET-GoT2D/T2D-GENES-09-07-2016-02:03:47:226-1135 - samples
The GoT2D study includes ~2800 samples, half T2D cases and half T2D controls, of Northern European ancestry sequenced over 3 three technologies: deep whole exome sequencing, low-pass (4x) whole genome sequencing, and OMNI 2.5M genotyping. Samples were ascertained to be phenotypically "extreme" (e.g....
EGAD00001002247 | EGA
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