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TranscriptomicsPancreatic cancercirculating tumor cells express a cell motility gene signature that predicts survival after surgery.
Most cancer deaths are caused by metastases, which are the end-results of circulating tumor cells (CTC) that detach from the cancer primary and succeed to survive in distant organs. The aim of the present study was to develop a gene signature of CTC and to assess its prognostic relevance after surge...
ORGANISM(S): Homo sapiens 
2012-12-18 | E-GEOD-18670 | biostudies-arrayexpress
Transcriptomicscolonic vs bone marrow MSC
We found that mesenchymal stem cells isolated from colonic tissue express significantly increased expression of Ptgs2 or cox-2 compared to that of mesenchymal stem cells isolated from the bone marrow, one of the most common tissues from which this cell type is derived. We hypothesized that the loca...
ORGANISM(S): Mus musculus 
2009-12-02 | E-GEOD-19233 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pancreas NS-928 cell lines modulated by COX-2
BxPc-3, Miapaca-2 and ASPC-1 cell lines were treated with 100 µM NS-398 in DMSO or with DMSO alone (control) for 48 h. Total-RNA from each sample was isolated with the RNeasy kit of Qiagen (Hilden, Germany) according to the manufacturer's protocol. The integrity of the isolated RNA was checked on an...
ORGANISM(S): Homo sapiens 
2010-07-06 | E-MEXP-1870 | biostudies-arrayexpress
TranscriptomicsPrimary and secondary CD8 T cells during acute and chronic LCMV infection
Understanding the response of memory CD8 T cells to persistent antigen re-stimulation and the role of CD4 T cell help is critical to the design of successful vaccines for chronic diseases. However, studies comparing the protective abilities and qualities of memory and naïve cells have been mostly pe...
ORGANISM(S): Mus musculus 
2011-08-22 | E-GEOD-30962 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of cervical epithelial cell responses to HIV-1
HIV-1 infections of women are mainly acquired through female reproductive tract where cervical and vaginal epithelial cells are the first line of defense. Although HIV-1 does not directly infect epithelial cells, HIV-1 obligatorily interacts with and crosses over epithelial layer to infect susceptib...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-42291 | biostudies-arrayexpress
TranscriptomicsExpression data from B6, Sle1b and Sle1b.BACSlamf6-H1 CD4+ T cells
We recently showed that the Slamf6 protein isoform Slamf6-H1 markedly diminishes T cell–dependent disease upon introduction of a Slamf6-H1–expressing transgene into the lupus-prone Sle1b mouse, which lacks this isoform. In this study we purified CD4+ T cells from Sle1b, Sle1b.Slamf6-H1, or B6 mice a...
ORGANISM(S): Mus musculus 
2013-04-23 | E-GEOD-31733 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human umbilical vein endothelial cells (HUVEC) treated with thrombin and leukotriene D4 (LTD4) with ethanol controls to delinate Cysteinyl leukotrienes mode of action
Cysteinyl leukotrienes (cysLT), i.e. LTC4, LTD4, and LTE4, are lipid mediators derived from the 5-lipoxygenase pathway. The cysLT receptors cysLT1-R and cysLT2-R are expressed on different target cells and mediate inflammatory reactions in tissue- and LT-R-specific ways. Though endothelial cells (EC...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-3589 | biostudies-arrayexpress
TranscriptomicsTP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer
Background: Gene expression profiling of breast carcinomas has increased our understanding of the heterogeneous biology of this disease and promises to impact clinical care. The aim of this study was to evaluate the prognostic value of gene expression-based classification along with established prog...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-40954 | biostudies-arrayexpress
TranscriptomicsEffect of lymphotoxin beta receptor blockade on microRNA expression in the spleen [AffyMircoRNA]
Follicular dendritic cells (FDC) are important stromal cells within the B cell follicles and germinal centres (GC) of secondary lymphoid tissues. FDC trap and retain native antigens on their surfaces in the form of immune complexes which they display to B cells, in order to select those cells with ...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-55720 | biostudies-arrayexpress
ProteomicsProteomic characterisation of Caenorhabditis elegans larval development
The nematode Caenorhabditis elegans (C. elegans) is often used as a model organism to study cell and developmental biology. Quantitative mass spectrometry has only recently been performed in C. elegans and, so far, most studies have been done on adult worm samples. Here we use quantitative mass spec...
ORGANISM(S): Caenorhabditis elegans 
2017-12-04 | PXD006676 | Pride
Caenorhabditis elegans Lc-ms Larvae Development 
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