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MetabolomicsDefective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in liver
Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. Mitochondrial gene expression is essential for OXPHOS biogenesis since core subunits of the complexes are mitochondrial-encoded. CO...
2024-07-19 | MTBLS9823 | MetaboLights
MetabolomicsMitochondrial respiration controls neoangiogenesis during wound healing and tumour growth

The vasculature represents a highly plastic compartment, capable of switching from a quiescent to an active proliferative state during angiogenesis. Metabolic reprogramming in endothelial cells (ECs) thereby is crucial to cover the increasing cellular energy demand under growth conditions. Here w...

2020-06-29 | MTBLS1764 | MetaboLights
UnknownAPOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.
Not available
S-EPMC6328941 | biostudies-literature
UnknownRegulation of COX Assembly and Function by Twin CX9C Proteins-Implications for Human Disease.
Not available
S-EPMC7909247 | biostudies-literature
UnknownMutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis.
Not available
S-EPMC3257963 | biostudies-literature
UnknownAPOPT1/COA8 ASSISTS COX ASSEMBLY AND IS OPPOSITELY REGULATED BY UPS AND ROS
Not available
S-SCDT-EMM-2018-09582 | biostudies-other
TranscriptomicsTranscription profiling of yeast rho0 cells (complete deletion of the mitochondrial genome), in cells with either a single defective enzyme or several, vs cells after prolonged treatment with the bc1 inhibitors myxothiazol or antimycin to analyse respiratory defects
The mitochondrial respiratory chain is composed of lipoprotein complexes imbedded in the inner mitochondrial membrane. This chain of enzymes transfers electrons from NADH and FADH2, provided from divers metabolic pathways, to oxygen. It couples the transfer of electrons to the translocation of proto...
ORGANISM(S): Saccharomyces cerevisiae 
2009-02-20 | E-MEXP-585 | biostudies-arrayexpress
ProteomicsVisualization of early ribosome assembly in action
Ribosomes, macromolecular machines producing a cell´s protein content, are formed from their RNA and protein components in a dynamic process referred to as ribosome assembly. While ribosome assembly in the cell starts with the successive synthesis of ribosomal RNA (rRNA) by the RNA polymerase holoen...
ORGANISM(S): Escherichia coli 
2022-09-05 | PXD030312 | Pride
Ribosome assembly 
ProteomicsComplexome profiling of mitochondria to study NDUFAF1 mediated complex I assembly in Yarrowia lipolytica
The aerobic yeast Yarrowia lipolytica is an established model organism to study mitochondrial protein complexes. Here we performed a complexome analysis of intact mitochondria to study the function of NDUFAF1 in the assembly of respiratory complex I. In the ndufaf1 deletion strain the PD module of t...
ORGANISM(S): Yarrowia lipolytica (Candida lipolytica) 
2022-12-21 | PXD033522 | Pride
Protein complexes Assembly 
Unknownp50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes.
Not available
S-EPMC4017649 | biostudies-literature
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