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Messenger RNA stability, localization, and translation are largely determined by sequences in their 3M-bM-^@M-2 untranslated regions (3M-bM-^@M-^YUTRs), which recruit regulatory proteins and RNAs. More than half of the mammalian genes generate multiple mRNA isoforms differing in their 3M-bM-^@M-2UTR...
ORGANISM(S): Homo sapiens 
CPEB1 regulates cellular function by post-transcriptionally controlling its targeted transcripts' translation. After bound to CPEs, CPEB1 recruits cytoplasmic poly (A) polymerase GLD2 to elongate the poly (A) tail for the maintenance of mRNA stability. The stability of mRNA is positively correlated ...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-04 | PXD020822 | Pride
Pancreatic cancer is a leading cause of cancer death worldwide. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is a fundamental translation regulatory factor regulating the polyadenylation process of messenger RNA. However, its biological functions in pancreatic cancer are poorly unde...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD047241 | Pride
Genome-wide mRNA targets of CPEB1 in muscle stem cells
CPEB1 and CPEB4-associated mRNAs in mice striatum
Muscle Stem Cells or satellite cells (SCs) are required for muscle regeneration. In resting muscles, SCs are kept in quiescence. After injury, SCs undergo rapid activation, proliferation and differentiation to repair damaged muscles. The transcriptome alteration during SC activation is well characte...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-05 | PXD018865 | Pride
Expression data from Neuro2a cells treated with siRNA targeting to Cpeb1 mRNA.
RNA seq of microglia from CPEB1-deficient and LPS-treated mice
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