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TranscriptomicsCPSF-160 iCLIP
We performed iCLIP of CPSF-160- GFP as CPSF160 was believed to be the main RNA-binding subunit of CPSF. To this end, we used a stable HeLa cell line that expresses GFP-CPSF160 in a doxycycline (Dox)-dependent manner. After GFP-CPSF160 was induced, we irradiated the cells with UV-C (wavelength=254nm)...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-MTAB-2939 | biostudies-arrayexpress
GenomicsCPSF-160 iCLIP
CPSF-160 iCLIP
PRJEB7303 | ENA
GenomicsCPSF controls PAS selection and epidermal differentiation
CPSF controls PAS selection and epidermal differentiation
PRJNA524364 | ENA
ProteomicsTargeted protein degradation of the CPSF complex by benzoxaboroles through sumoylation
Benzoxaboroles (BoBs) feature a boron-heterocyclic core and are an important innovation in the development of drugs against a range of pathogens and other pathologies. A broad spectrum of pharmacology is associated with chemically diverse BoB derivatives and includes multiple modes-of-action (MoA) a...
ORGANISM(S): Trypanosoma brucei 
2026-02-13 | PXD074414 | Pride
Cpsf benzoxaboroles sumoylation 
ProteomicsStructural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex
Structural study of the polyA signal recognition by the human CPSF using X-ray crystallography, cross-linking MS, pull-downs and fluorescence polarisation assays.
ORGANISM(S): Homo sapiens (Human) 
2017-12-18 | PXD008122 | Pride
Chemical cross-linking Structural proteomics Rna Dss Polya 
TranscriptomicsReconstitution of CPSF active in polyadenylation: Recognition of the polyadenylation signal by WDR33
Cleavage and polyadenylation specificity factor (CPSF) is the central component of the 3' processing machinery for polyadenylated mRNAs in metazoans: CPSF recognizes the polyadenylation signal AAUAAA, providing sequence specificity in both pre-mRNA cleavage and polyadenylation, and catalyzes pre-mRN...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-61123 | biostudies-arrayexpress
UnknownStructural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.
Not available
S-EPMC6900284 | biostudies-literature
UnknownStructural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.
Not available
S-EPMC5760199 | biostudies-literature
TranscriptomicsCPSF controls PAS selection and epidermal differentiation
Alternative polyadenylation (APA) is a regulatory mechanism that controls gene expression level and function through the usage of different transcription termination sites, but how APA is regulated to influence epidermal tissue differentiation remains under-characterized. Leveraging 3’READS+, we ide...
ORGANISM(S): Homo sapiens 
2020-11-02 | GSE127223 | GEO
TranscriptomicsGenome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length: CLIP
Through alternative polyadenylation, human mRNAs acquire longer or shorter 3' untranslated regions, the latter typically associated with higher transcript stability and increased protein production. To understand the dynamics of polyadenylation site usage, we mapped transcriptome‐wide both binding s...
ORGANISM(S): Homo sapiens 
2012-05-15 | E-GEOD-37398 | biostudies-arrayexpress
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