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Proteomics: Interacting partners of Trypanosoma brucei CPSF73 in the presence of mRNA processing inhibitor, AN7973
T. brucei CPSF73 endogenously TAP-tagged at the C-terminal was affinity purified after treating the cells for 15 min with AN7973 at 10x EC50. Three technical replicates were used. 3 technical replicates of untreated cells served as controls. Inducible GFP-TAP with and without treatment served as add...
ORGANISM(S): Trypanosoma brucei 
2022-10-19 | PXD033513 | Pride
An7973 Tap Cpsf73 
GenomicsEffect of INTS11, INTS9, CPSF73 knockdown on transcription
Effect of INTS11, INTS9, CPSF73 knockdown on transcription
PRJNA854600 | ENA
GenomicsTargeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration and invasion
Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration and invasion
PRJNA784278 | ENA
GenomicsTargeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration and invasion
Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration and invasion
PRJNA784305 | ENA
UnknownTargeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal.
Not available
S-EPMC9385686 | biostudies-literature
UnknownXrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity.
Not available
S-EPMC5830926 | biostudies-literature
UnknownMolecular details of the CPSF73-CPSF100 C-terminal heterodimer and interaction with Symplekin.
Not available
S-EPMC10688271 | biostudies-literature
TranscriptomicsTargeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration and invasion
Cleavage by the endonuclease CPSF73 and polyadenylation of nascent RNA is an essential step in co-transcriptional mRNA maturation, and abnormal poly(A) site choices have been associated with human diseases, including cancer. Recent work has surprisingly identified CPSF73 as a promising drug target f...
ORGANISM(S): Homo sapiens 
2021-12-05 | GSE189723 | GEO
TranscriptomicsTargeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration and invasion
Cleavage by the endonuclease CPSF73 and polyadenylation of nascent RNA is an essential step in co-transcriptional mRNA maturation, and abnormal poly(A) site choices have been associated with human diseases, including cancer. Recent work has surprisingly identified CPSF73 as a promising drug target f...
ORGANISM(S): Homo sapiens 
2021-11-30 | GSE189746 | GEO
GenomicsXrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity
Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity
PRJNA429385 | ENA
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