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A new NO-independent immunomodulatory function for iNOS in regulating itaconate production via mitochondrial protein-protein interaction with IRG1
iNOS modulates itaconate metabolism by a novel conformation-dependent protein-protein interaction separate from iNOS-mediated NO generation.
ORGANISM(S):
Homo sapiens (Human)
2026-02-20
|
PXD048712
|
Pride
Macrophages
Tca cycle by cis-aconitate decarboxylase
Inos and irg1
Cite
Atherosclerosis quantification and cardiovascular risk: the ISCHEMIA trial.
Not available
S-EPMC11439108
|
biostudies-literature
Cite
Extended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: international, prospective, propensity score-weighted cohort study.
Not available
S-EPMC11894929
|
biostudies-literature
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